Clinical Trials Logo

Clinical Trial Summary

The research project is aiming to examine the muscular adaptations to resistance training (RT), detraining (DT) and repeated RT (i.e. retraining). The research project will also examine differences in muscular adaptations between 20 weeks of continuous RT and 20 weeks of intermittent RT including a 10-week DT period in the middle of the training intervention. This is randomized controlled trial in which the research participants will be randomized into discontinuous and continuous groups (both n=~20). Both will be doing a 2-3-week familiarization and control period at the start. Then in the former there will be an initial strength training period (10-wks), a DT period (10-wks), and a second strength training (retraining) period (10-wks). The second group includes a 10-wk non-training control period (10-wks) followed by a RT period (20-wks). Participants will be young, healthy men and women (age 18-35, which 50% are females) with no systematic RT experience during the last 6 months. Measurements will be completed before and after each study period. Body composition will be measured via bioelectrical impedance analysis (BIA) and 3D body scans. Dynamic leg press and elbow flexion one repetition-maximum (1RM) will be used to test maximal strength. Anaerobic performance and strength endurance will be tested in elbow flexion and dynamic leg press using RM tests. Vastus lateralis (VL) and biceps brachii muscle cross-sectional area (CSA) will be assessed via ultrasound. Muscle biopsies of the VL muscle will be obtained to assess changes in muscle fiber morphology and factors regulating and associated with the hypertrophic processes and metabolism. Blood samples will be collected to analyze changes in metabolism and physiology. A rating of perceived exertion (RPE) during training will be collected after every exercise to ensure proper training intensity. Finally, nutrition and habitual physical activity will be assessed with 4-day diet diaries and physical activity questionnaires before the intervention and during each 10-week period.


Clinical Trial Description

It is well known that RT increases skeletal muscle size and strength. However, there seems to be a difference in increases in muscle size (termed hypertrophy) and strength in upper and lower limb musculature in untrained population after RT. Moreover, there is large inter-individual variation in the adaptations gained through RT. Also at the moment, the responses to de- and retraining are not well known, and new research designs for investigating possible muscle memory are needed. Muscle mass and strength, once achieved with RT, can be obtained faster with subsequent retraining if the initial adaptations were lost due to inactivity. RT causes many molecular and cellular changes in myofibers that aid in hypertrophic processes, yet their adaptations to DT and contribution to muscle memory are still marginally researched. It is, therefore, essential to widen our knowledge about the permanence of physiological adaptations in skeletal muscle to periods of DT and repeated exposure to RT. The primary objectives to achieve by this project are: 1. to determine the magnitude of 10-week RT period on upper and lower limb maximal dynamic strength and muscle size compared to the non-training control group 2. to determine whether the responses to 20-week continuous RT differs in adaptations in maximal strength and muscle hypertrophy from two 10-week RT periods separated by a 10-week detraining period 3. to identify molecular and cellular biomarkers explaining responses to RT, detraining and retraining ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05553769
Study type Interventional
Source University of Jyvaskyla
Contact
Status Completed
Phase N/A
Start date March 1, 2022
Completion date December 31, 2022

See also
  Status Clinical Trial Phase
Completed NCT05820399 - Guayusa Extract on Exercise Training N/A
Active, not recruiting NCT04295590 - Impact of Augmenting Exercise Intensity vs. Frequency N/A
Completed NCT05934578 - Lymphatic Function in Patients With Fontan Circulation: Effect of Physical Training N/A
Completed NCT03563430 - Effects of Different Recovery Methods on Lactic Acid Removal, Flexibility, Strength, and Endurance N/A
Not yet recruiting NCT06453473 - Transfer Effects of Stationary Bicycle Perturbation Training on Older Adults' Cycling Skills N/A
Completed NCT02981667 - Higher Enjoyment in Response to High Intensity Interval Training Versus Moderate Intensity Continuous Exercise N/A
Completed NCT05255497 - The Effect of Sensorial Biodex Balance Balance System Exercises in Diabetic Neuropathy N/A
Completed NCT04084535 - Effects of High Intensity Interval Training (HIIT) vs. Inspiratory Muscle Training on the Recovery After a Maximal Apnea. N/A
Completed NCT04384185 - Combined Treatment of Manual Therapy and Therapeutic Exercise in Patients With Low Back Pain N/A
Completed NCT04114175 - Spinal Stabilization Exercises in Individuals With Transtibial Amputatıon N/A
Completed NCT02958657 - Effect of Exercise on Platelet Reactivity After Myocardial Infarction N/A
Not yet recruiting NCT00808600 - Empowerment of Lung and Heart-lung Transplant Patients N/A
Completed NCT04450134 - Histamine H1/H2 Receptors and Training Adaptations N/A
Completed NCT02999139 - Analytic, Prospective Cohort Study of Athletes Enrolled in an Exercise Training Intervention
Not yet recruiting NCT04366414 - Breathing Protocol in Breath-hold Divers N/A
Recruiting NCT04311736 - Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults N/A
Recruiting NCT03754478 - Follow-Up of Fitness in Overweight Patients Treated With Physical Activity
Completed NCT05402527 - Fish Nutrient Supplementation in High-intensity Functional Training N/A
Completed NCT06138951 - Exercise Dose-response and Protein Requirements N/A
Recruiting NCT06260579 - Home-based Exercise and Physical Activity Intervention After Kidney Transplantation: Impact of Exercise Intensity N/A