Protein Supplementation and Skeletal Muscle Healing Process

Skeletal Muscle Damage Clinical Trial

Official title: Effects of Protein Supplementation on Skeletal Muscle Regeneration and Healing Process Following Exercise-induced Aseptic Injury

Status Completed

Clinical Trial Summary

In this study the investigators utilized protein supplementation over an 8-day period following eccentric exercise-induced muscle damage in order to test the initial hypotheses : i) protein supplementation after exercise-induced muscle injury affects exercise-induced aseptic inflammation and muscle performance.

Clinical Trial Description

The objective was to examine weather protein supplementation is able to affect the inflammatory response as well as recovery of muscle performance following an intense eccentric exercise protocol. In a double-blind, counterbalanced design, 14 men received either Placebo (PLA) or milk protein isolate (PRO) for 8 consecutive days following a single bout of exercise (300 eccentric contractions at 30 deg/sec). In both conditions, performance was assessed at baseline, immediately post-exercise, 2h post-exercise and daily for 8 consecutive days. Blood samples were collected at baseline, 2h post-exercise and daily for the remaining 8 days. Muscle biopsies from vastus lateralis were collected at baseline as well as at day 2 and day 8 of the post-exercise period. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Exercise-induced Aseptic Inflammation
• Inflammation
• Intracellular Signaling in Skeletal Muscle
• Proteasome Activation
• Skeletal Muscle Damage
• Skeletal Muscle Performance

• NCT number: NCT02816411
• Study type: Interventional
• Source: University of Thessaly
• Status: Completed
• Phase: N/A
• Start date: May 2014
• Completion date: July 2016