Skeletal Muscle Damage Clinical Trial
Official title:
Effects of NAC Supplementation on Immune Function, Inflammatory and Performance Responses of Elite Soccer Players Participated in Three Repetitive Games.
In this investigation the investigators utilized NAC supplementation to boost GSH availability during an one-week-microcycle consisting of three soccer games, in order to test the hypotheses that: i) antioxidant supplementation may enhance the recovery of performance and physiological stress variables following multiple match-plays and ii) redox status perturbations are critical in regulating the inflammatory response and repair in skeletal muscle, following repetitive exercise-induced muscle injuries.
After exercise-induced muscle microtrauma the thiol/disulfide couple of reduced (GSH) and
oxidized glutathione (GSSG) is a key regulator of important transcriptional pathways that
control the inflammatory response and recovery of skeletal muscle.
The objective was to examine how thiol-based antioxidant supplementation affects the muscle
damage, oxidative stress, inflammatory and immune responses, as well as the level of
post-game fatigue and muscle's recovery kinetics in response to three soccer games within a
week. Participants were randomly assigned to one of four groups: i) Experimental-NAC
[EXP-NAC, N=10, participated in daily training sessions and three games and received NAC (20
mg/kg/day)], ii) Experimental-Placebo (EXP-Pla, N=10, participated in daily training sessions
and three games and received Placebo), iii) Control-NAC [CON-NAC, N=10, participated in daily
training sessions only and received NAC(20 mg/kg/day)] and iv) Control-Placebo (CON-Pla,
N=10, participated in daily training sessions only and received Placebo). Blood samples were
collected at baseline, post-games and daily during recovery. Performance was assessed at
baseline and daily during recovery.
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