Endoscopic Treatment of Salivary Glands Affected by Sjögren's Syndrome

Status Active, not recruiting

Clinical Trial Summary

Sjögren's syndrome (SS) is an autoimmune inflammatory disorder of the exocrine glands. It particularly affects the lacrimal and salivary glands. Severe dry mouth and eyes are frequently reported as presenting symptoms. These symptoms are in many cases accompanied by nonspecific symptoms, such as malaise and fatigue. In addition, extraglandular manifestations, like purpura, polyneuropathy, and arthritis, can be present. SS affects mainly women with a female/male ratio of 9:1 and can occur at all ages. Due to the irreversible damage to the saliva producing cells, the quantity and quality of saliva reduces. The progressive nature of the syndrome results in a further reduction of salivary flow. Due to hyposalivation the patients suffer from progressive dental decay, dental erosion, severe dry mouth complaints (i.e. eating and swallowing problems, lack of taste), inflammation of the oral mucosa and lack of retention of removable dentures. Overall, this can be qualified as a reduction in the quality of life. Until now no effective (palliative) therapy to relieve dry mouth complaints is available. A recent case series study suggests that an endoscopic technique (sialoendoscopy) is able to alleviate the symptoms of patients suffering from SS. In this technique the ducts of the salivary glands are rinsed with saline and cortisone and possible strictures are dilated. It is hypothesised that performing a sialoendoscopic treatment will raise or restore (un)stimulated salivary flow levels and improve the reported mouthfeel score.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02112019
Study type	Interventional
Source	VU University Medical Center
Contact
Status	Active, not recruiting
Phase	N/A
Start date	June 2014
Completion date	December 2017

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05946941` - A Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults With Active Sjögren's Syndrome	Phase 3
Completed	`NCT05633524` - HRR as a Novel Biomarker in Sjögren's Syndrome
Terminated	`NCT02843659` - Proof of Concept Study to Evaluate the Efficacy and Safety of BMS-931699 (Lulizumab) or BMS-986142 in Primary Sjögren's Syndrome	Phase 2
Completed	`NCT04129164` - A Study to Evaluate the Efficacy and Safety of VIB4920 in Participants With Sjögren's Syndrome	Phase 2
Completed	`NCT04798911` - SS-INQ Information Needs Questionnaire in Sjögren's Syndrome
Recruiting	`NCT05605665` - Low-dose Interleukin-2 and Rapamycin on sjögren's Syndrome	Phase 1/Phase 2
Completed	`NCT02833311` - e-Mobile Tablet for People With Chronic Conditions	N/A
Completed	`NCT04572841` - Safety, Tolerability, Pharmacokinetics, and Therapeutic Efficacy of SAR441344 in Primary Sjögren's Syndrome (pSjS)	Phase 2
Completed	`NCT04111341` - A Clinical Trial to Evaluate the Safety and Efficacy of Traditional Chinese Medicine in Sjögren's Syndrome.	Phase 2
Recruiting	`NCT03060005` - Is Sjögren's Syndrome Associated With Meibomian Gland Dysfunction ?	N/A
Terminated	`NCT01316770` - Dexamethasone Irrigation of the Parotid Glands in Primary Sjögren's Syndrome Subjects	Phase 2
Completed	`NCT02422407` - A Longitudinal, Observational Biomarker Study in Participants With Primary Sjogren's Syndrome	N/A
Completed	`NCT01160666` - Efficacy and Safety of Belimumab in Subjects With Primary Sjögren's Syndrome	Phase 2
Active, not recruiting	`NCT02849093` - Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome.	N/A
Recruiting	`NCT03983408` - Impact of Korean Red Ginseng on Fatigue in Patients With Rheumatic Disease	N/A
Completed	`NCT00873496` - Effects of Hydroxychloroquine on Oral Complaints of Sjögren Patients	N/A
Completed	`NCT05680064` - The Effect of Chewing Gum, Exercises of the Tongue, Lip, Jaw on Salivation, Xerostomia, Dysphagia in Sjögren's Syndrome	N/A
Recruiting	`NCT02110446` - Evaluation of the Efficacy and the Mechanism of Chinese Herbal Formula SS-1 for Sjögren's Syndrome	Phase 2
Recruiting	`NCT02855658` - Modulation of Immunity-related Gene Expression Under the Chinese Herbal Formula SS-1 Treatment for Sjögren's Syndrome	Phase 2
Recruiting	`NCT03434106` - Sjögren's Syndrome Is Associated With Meibomian Gland Dysfunction	N/A