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Clinical Trial Summary

Children, adolescents, and young adults with malignant and non-malignant conditionsundergoing an allogeneic stem cell transplantation (AlloSCT) will have the stem cells selected utilizing α/β CD3+/CD19+ cell depletion. All other treatment is standard of care.


Clinical Trial Description

Patients wiith selected malignant or non-malignant conditions meeting eligibility criteria will be enrolled on this study. Patients will receive one of either full intensity, reduced intensity, or reduced toxicity conditioning appropriate based on disease, disease status, organ function and performance status and will undergo α/β T-cell and CD 19+ B cell depleted alloSCT. Patients will be following for engraftment, chimerism, immune reconstitution, GVHD and QOL. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04099966
Study type Interventional
Source New York Medical College
Contact Mitchell S Cairo, MD
Phone 9145942150
Email mitchell_cairo@nymc.edu
Status Recruiting
Phase Phase 2
Start date April 1, 2021
Completion date December 31, 2026

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