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Dronabinol for Pain and Inflammation in Adults Living With Sickle Cell Disease

Sickle Cell Disease Clinical Trial

Official title:
Dronabinol for Pain and Inflammation in Adults Living With Sickle Cell Disease

Clinical Trial Summary

This study is designed to address the feasibility of a randomized, double masked, cross-over study of dronabinol as a palliative agent in the treatment of pain, inflammation, and other complications of sickle cell disease (SCD).

Clinical Trial Description

The Primary Hypothesis is that such a study will be feasible as defined by subject adherence to study medication and study procedures and avoidance of other cannabinoid containing substances during the trial period as well as by ability to mask subjects and investigators to treatment assignment Secondary hypotheses are: Dronabinol will: Reduce patient-reported pain interference Reduce patient-reported pain scores and change patient-reported pain quality. Reduce use of opioid pain medications. Improve patient-reported stiffness, nausea and vomiting, sleep, mood, anxiety, and social functioning. Reduce markers of inflammation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03978156
Study type Interventional
Source Yale University
Contact
Status Terminated
Phase Phase 1
Start date July 26, 2019
Completion date January 1, 2021
View Details
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