Shock Clinical Trial
Official title:
Multiscale Approach to Describe the Evolution of Molecular Biomarkers in Acute Heart Failure Induced by Shock
The relationship between shock, ischemia and reperfusion (I/R) injury, hemodynamic
instability, systemic inflammatory response syndrome and multiorgan failure has been
extensively investigated, but there is no consensus on the trigger mechanisms of tissue
injury at the molecular level.
Current therapies are targeted to reduce symptoms of shock and multiorgan damage but they are
unable to act at the "beginning of the cascade", because of the lack of a model explaining
the molecular basis of shock induced tissue injury and ensuing organ damage.
The present observational study is aimed at identifying the molecular triggers of acute heart
failure (HF) induced by shock and to identify inflammatory mediators and markers that are
activated in shock, with a particular emphasis on the role of uncontrolled proteolytic
activity.
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