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Genomics in Infection and Sepsis to Predict Organ Dysfunction and Outcomes in Sepsis

Sepsis Clinical Trial

Official title:
Genomic Approaches for Predicting Severity of Organ Dysfunction and Outcomes in Sepsis: a Prospective Cohort Study in Adult Critically Ill Patients With Sepsis

Clinical Trial Summary

This is a prospective cohort study using gene expression to study patients with infection and sepsis from pneumonia.

Clinical Trial Description

This is a prospective cohort study using single cell transcriptomic profiling and plasma DNA tissue mapping on patients with pneumonia with or without sepsis. The major application of the investigator's study would be the discovery of gene expressions in different leucocytes and plasma DNA associated with each type of organ dysfunction in sepsis. These include cardiovascular, respiratory, hepatic, renal, neurological and haematological dysfunction. This would help prediction, diagnosis and development of therapies to treat sepsis. Leucocyte single cell transcriptome and plasma DNA tissue mapping may addresses the limitations of current evidence in 3 ways: (1) differentiate patients with uncomplicated pneumonia versus pneumonia with associated sepsis, (2) correlation with types and severity of organ dysfunction and (3) identifying molecular phenotypes of sepsis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04199962
Study type Observational
Source Chinese University of Hong Kong
Contact Lowell Ling, FCICM
Phone +852 3505 1311
Email lowell.ling@cuhk.edu.hk
Status Recruiting
Phase
Start date December 12, 2019
Completion date December 31, 2023
View Details
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