Sepsis Clinical Trial
Official title:
Acute Pulmonary and Systemic Inflammation in Mechanically Ventilated Intensive Care Patients
Acute respiratory distress syndrome (ARDS) is a devastating form of acute lung inflammation,
that may be caused by a variety of insults with pulmonary and systemic infectious disease
being the most common predisposing factor. Sepsis, on the other hand, represents the systemic
inflammatory response to an invading pathogen, which may inflict damage upon the host through
organ dysfunction. ARDS and sepsis are heterogenous clinical conditions that have a high
mortality, and both diseases involve a complex interplay of different inflammatory mediators
and cell types. It has been suggested that locally released inflammatory mediators pass from
the lungs into the bloodstream following ARDS, triggering systemic inflammation. Conversely,
it is possible that severe systemic inflammation may lead to ARDS by an influx of
inflammatory mediators from the bloodstream to the lungs. However, the time course and the
possible pathways for this transmission of disease have yet to be established.
Investigators hypothesize that:
1. Primary systemic inflammation is followed by a secondary pulmonary inflammatory response
2. Primary pulmonary inflammation is followed by a secondary systemic inflammatory response
3. Both primary and secondary inflammatory responses are characterized by the appearance of
pro-inflammatory cytokines, inflammatory cells and production of collagen-like proteins
(termed 'lectins')
4. The inflammatory response is most pronounced in the primary afflicted compartment.
n/a
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