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Reducing Elevated Heart Rate in Patients With Severe Sepsis by Ivabradine — REHSI  

Sepsis, Severe Clinical Trial

Official title:
Reducing Elevated Heart Rate in Patients With Severe Sepsis by by the "Funny Channel" Current (If) Inhibitor Ivabradine

Clinical Trial Summary

REHSI is a prospective, multi-center, open label, randomized, controlled two arms, to evaluate the ability of ivabradine to reduce an elevated heart rate in septic shock patients. The primary end point is the reduction of heart rate within 24 hours. This trial will randomize 70 patients (men and women, aged ≥ 18 years) with newly diagnosed Septic Shock (despite adequate fluid resuscitation, were still requiring high-dose norepinephrine (NE) to maintain a mean arterial pressure (MAP) ≥65 mmHg , and had a tachycardia >100 beats per minute (bpm). Treatment period will last 4 days. All patients will be followed for up to six months.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03367026
Study type Interventional
Source Peking Union Medical College Hospital
Contact
Status Not yet recruiting
Phase N/A
Start date January 1, 2018
Completion date June 30, 2021
View Details
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