Schizophrenia Clinical Trial
Official title:
Epigenetic Regulation of Brain-Derived Neurotrophic Factor (BDNF) Gene Expression According to Response to Cognitive Remediation in Schizophrenia
This study is a randomised and controlled trial that aims to investigate whether Cognitive Remediation Therapy (CRT) can modulate epigenetic mechanisms by changing methylation levels of BDNF gene in patients with Schizophrenia.
OBJECTIVES: To investigate whether Cognitive Remediation Therapy (CRT) can modulate
epigenetic mechanisms by changing methylation levels of BDNF gene. It also aims to test
whether BDNF valine-66-methionine (Val66Met) polymorphism influences CRT treatment outcome
among people with schizophrenia.
SAMPLE AND METHODS: A randomized and controlled study will be carried out with two groups:
patients receiving CRT and patients in control condition without any cognitive intervention
and receiving Treatment as Usual (TAU). Methylation levels of BDNF gene at different sites
will be contrasted before and after treatment. Additionally, neurocognition profile, level of
symptoms and psychosocial functioning will also be tested. CRT outcomes will be investigated
in a mixed model for repeated measures.
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