Imaging Synapses With [11C] UCB-J in the Human Brain

Status Recruiting

Clinical Trial Summary

The purpose of this study is to utilize the radioactive positron emission tomography (PET) tracer [11C]UCB-J to test the neural synaptic pruning hypothesis of schizophrenia. This imaging method allows for the quantification of synaptic density in the living human brain and has the unprecedented ability to directly examine the synaptic pathology underlying neuropsychiatric disease. The neural synaptic pruning hypothesis posits that a key pathogenic process of schizophrenia is the over-exuberant elimination of neural synapses during development. The confirmation of reduced synaptic density in schizophrenia as evidenced by [11C]UCB-J has the potential to lead to a number of ground-breaking clinical innovations, such as laboratory-based diagnostics and prognostics, and novel, disease-modifying treatments.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Schizophrenia

Clinical Trial Details

NCT number	NCT04038840
Study type	Interventional
Source	Stanford University
Contact	Study Coordinator
Phone	650-849-0552
Email	brain-research@stanford.edu
Status	Recruiting
Phase	Phase 1
Start date	August 1, 2019
Completion date	December 2025

View Details

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