Schizophrenia Clinical Trial
Official title:
Clinical Trials for Neuroimaging and Electrophysiology in Schizophrenic Patients With Negative Symptoms Using Transcranial Direct Current Stimulation
The investigators conducted a randomized controlled trial to reveal the effect of tDCS on negative symptoms in patients with schizophrenia and its underlying mechanism using the neuroimaging and electrophysiology.
The project will investigate the use of a novel technique, transcranial direct current
stimulation (tDCS) in the treatment of patients with schizophrenia. tDCS permit the
application of an extremely weak continuous electrical current to the brain through an anode
and a cathode applied on the scalp. Anodal stimulation appears to increase brain activity
whereas cathodal stimulation has the opposite effect.
Using anodal and cathodal tDCS the investigators aimed to treat negative symptoms of
schizophrenia. The investigators plan to apply tDCS such that it can simultaneously increased
activity in the frontal brain areas and reduce activity over temporoparietal cortex, 2 areas
involved in the physiopathology of the disease. Real active stimulation will be compare to a
sham condition in 44 patients (22 in each group). 44 patients will be included in Seoul
National University Hospital
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