Schizophrenia Clinical Trial
Official title:
Predictive Coding Abnormalities in Psychosis: EEG and fMRI
NCT number | NCT03068806 |
Other study ID # | MH058262 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | December 1, 2014 |
Est. completion date | May 11, 2018 |
Verified date | November 2018 |
Source | San Francisco Veterans Affairs Medical Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This is a research study designed to examine how the psychiatric illness called schizophrenia affects brain function and thinking abilities such as attention and memory during simple computer-based tasks, and how measures of brain function are related to performance. The investigators do this by looking at brain activity using electroencephalography (EEG) and magnetic resonance imaging (MRI). The investigators compare participants' results to the activity in their brain as well as clinical measures and questionnaires also completed during this study.
Status | Completed |
Enrollment | 202 |
Est. completion date | May 11, 2018 |
Est. primary completion date | May 11, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility |
Inclusion Criteria: - The subject population will include 18 to 75 year old participants of any gender, race, and ethnicity. All subjects will be able to speak and understand English. Schizophrenia subjects: 1. Patients must be diagnosed with DSM-IV schizophrenia, schizophreniform, or schizoaffective disorder based on a SCID-P interview. Comparison subjects: 1. Control participants must not have past or present Axis I diagnosis as determined by the SCID-NP. Exclusion Criteria: - All subjects: 1. A hearing deficit greater than 40dB in both ears detected during the hearing test 2. Substance dependence, as per clinical judgment, in the past 1 year (except caffeine and nicotine) 3. A history of significant medical/neurological disease such as cardiac, thyroid, renal, hepatic or neurological 4. History of head injury with loss of consciousness greater than 15 minutes 5. Any other condition or medication, which in the opinion of the investigator would preclude participation in the study. 6. Non-English speaking. Comparison subjects: 1. Any first-degree relative with schizophrenia or bipolar disorder. |
Country | Name | City | State |
---|---|---|---|
United States | San Francisco VA Medical Center | San Francisco | California |
Lead Sponsor | Collaborator |
---|---|
San Francisco Veterans Affairs Medical Center |
United States,
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Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | EEG | Electroencephalography, measures signals from the brain while participants conduct specific tasks that measure memory and attention. | Day 1 | |
Primary | MRI | Magnetic Resonance Imaging, measures activity in, and takes detailed pictures of the brain while participants conduct specific tasks that measure memory and attention. | Day 1 | |
Primary | Memory and Attention tasks | Tasks involve saying words, pressing buttons at specific times, listening, and viewing pictures. | Day 1 |
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