Emotional Response in Psychiatric and Control Participants

Schizophrenia Clinical Trial

Official title:

Emotional Response in Psychiatric and Control Participants

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03056781
• Other study ID #: 2016-2945
• Status: Completed
• Phase: N/A
• Start date: February 15, 2017
• Est. completion date: August 1, 2018

Study information

• Verified date: December 2018
• Source: University of California, Irvine
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this research is to understand how the emotions of people with different mental health concerns (e.g., people with schizophrenia, people with major depressive disorder) differ from individuals without mental health concerns. A large body of literature suggests that people with mental illnesses have emotional abnormalities compared to healthy individuals, but a number of these abnormalities are not well understood. For example, often people with schizophrenia report on questionnaires that they experience fewer pleasant emotions when talking with other people, but some evidence suggests these individuals report a similar amount of pleasant emotion when they are actually engaged in a pleasant activity. Thus, it is unclear the extent to which reports of emotional abnormalities extend to a more real-world setting. In the tasks in the current proposal, participants will engage in a series of tasks designed to assess their emotional functioning. These tasks involve viewing emotional stimuli on the computer, engaging in social interactions, and consuming small amounts of food. In all tasks, participants will make ratings of their experiences of pleasure (and displeasure). We will then compare the experiences of patient groups to those of healthy individuals to test how emotional ratings might differ across these tasks.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 46
• Est. completion date: August 1, 2018
• Est. primary completion date: August 1, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• For control participants, you are eligible to participate in this study if you are between 18 and 65 years of age, you are fluent in English, and you have not been clinically diagnosed with a psychiatric disorder.

• For psychiatric patients, you are eligible to participate in this study if you are between 18 and 65 years of age, you are fluent in English, and you have been clinically diagnosed with schizophrenia, schizoaffective disorder, or depression with no recent hospitalization or changes in your psychiatric medications.

Exclusion Criteria:

• For control participants, you are not eligible to participate in the study if you have a history of stroke or a current history of substance or alcohol dependence. You are also not eligible to participate in this study if you have had a diagnosis of substance abuse in the past three months. You are not eligible to participate if you have a current or past history of a major medical illness, significant tremors, a history of a head injury or prolonged unconsciousness.

• For psychiatric patients, you are not eligible to participate in the study if you have had major changes to your psychotropic medications within the last two months, have a history of stroke or a current history of substance or alcohol dependence. You are also not eligible to participate in this study if you have had a diagnosis of substance abuse in the past three months, a current or past history of a major medical illness, significant tremors, or a history of a head injury or prolonged unconsciousness.

Related Conditions & MeSH terms

• Emotions
• Schizophrenia

Intervention

Behavioral:
• social interaction
Participants will engage in a social interaction with another person
• food consumption
Participants will be offered food stuffs to eat/drink

Locations

Country	Name	City	State
United States	Social Ecology 1	Irvine	California

Sponsors (1)

Lead Sponsor	Collaborator
University of California, Irvine

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Social Anhedonia Scale	measures social anhedonia	1 day
Primary	Physical Anhedonia Scale	measures physical anhedonia	1 day
Primary	EEG activity	physiological parameter	1 day
Primary	Verbal behavioral rating	how many words are spoken throughout the task	1 day
Primary	Non-verbal behavioral rating	how many gestures are made throughout the task	1 day
Primary	International Personality Item Pool questionnaires	measure of personality	1 day
Secondary	Following Affective States test	questionnaire re: how much participants follow or ignore their emotions	1 day
Secondary	AMNART	measure of verbal IQ	1 day
Secondary	MMSE	measure of mental status	1 day