Schizophrenia Clinical Trial
Official title:
Relationships of One-carbon Cycle Pathway With Psychopathology and Metabolic Abnormalities in Patients With Schizophrenia and Potential Intervention Strategy With Folic Acid and Vitamin B12
The investigators study aims are:
1. To investigate folate, vitamin B12, and homocysteine levels in patients with
schizophrenia.
2. To evaluate the relationships among folate, vitamin B12, and homocysteine levels,
genetic variants of one-carbon cycle pathway, psychopathology, including positive
symptoms, negative symptoms, and cognition, and metabolic abnormalities in patients
with schizophrenia.
3. For patients with low folate levels, the investigators would like to conduct a 24-week
double-blinded, placebo-controlled of folic acid (5 mg/d) and vitamin B12 (500 ug/d)
supplementation study to know whether combination of folic acid and vitamin B12 can
improve patients' psychopathology or metabolic profiles, and the effects of genetic
variants in one-carbon cycle pathway on treatment response.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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