Schizophrenia Clinical Trial
— SAILLANCE1Official title:
Study of Cognitive and Emotional Factors Influencing the Visual Exploration Among Patients With Schizophrenia
Verified date | August 2020 |
Source | University Hospital, Lille |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Background:
Patients with schizophrenia are abnormally disturbed by information onsets, which may result
in a disadvantage in filtering relevant information. It seems that they accord the same
importance to all objects in a scene without taking into account the relevance of objects
(cognitive salience) or their emotional charge (salience emotional).
The paradigm of change blindness offers the interesting possibility of studying sensitivity
to the sudden irruption of visual information with ecological stimuli in schizophrenia. An
increased attentional capture by the irruption of visual information would suggest better
performance in patients than in healthy controls. Moreover, patients are disturbed to
processing of emotional information, in this way we would like to measure the impact of
emotional salience on the visual exploration.
Main aim:
The main objective is to evaluate, if patients with schizophrenia quickly detect changes
occurring on irrelevant objects in the understanding of the scene.
Secondary objectives:
To evaluate in patients with schizophrenia the impact of emotional salience using the same
paradigm.
To separate an explicit response (motors responses) with an implicit response (eye tracking
measures).
Methodology:
30 patients with schizophrenia and 30 healthy controls were asked to detect changes in 96
scenes with 0 or 1 change (neutral or emotional changes). We will measure the participants'
speed and accuracy in explicitly reporting the changes via motor responses and their capacity
to implicitly detect changes via eye movements.
Status | Completed |
Enrollment | 42 |
Est. completion date | November 17, 2019 |
Est. primary completion date | November 17, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Normal or corrected vision - Affiliate to a social security system - For group of patients with schizophrenia : diagnosis of schizophrenia based on the standard DSM-IV criteria and patients will be clinically stable at the testing time Exclusion Criteria: - History of neurological illness - Pregnant and nursing women - Drugs use in the last 24 hours - Acute ocular disorder - Under tutorship, curatorship or deprived of liberty - For controls group : be free DSM-IV axis-I diagnoses according the MINI test. |
Country | Name | City | State |
---|---|---|---|
France | University Hospital, Lille | Lille |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Lille |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | response time | The explicit response of the participants will be measure behaviourally by response time before the detection of neutral stimuli. | 42 months | |
Secondary | sensitivity index | Performances will be measure by a sensitivity index (D prime) which considers the number of correct detections compared with the missed detections and false alarms; thus it evaluates the capacity to discriminate the signal against a background noise. | 42 months | |
Secondary | implicit response | The implicit response will be measure by the localization and duration of fixations | 42 months | |
Secondary | emotional response | The emotional response will be measure by the localization, duration of fixations and performances for the detection of emotional stimuli | 42 months |
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