Schizophrenia Clinical Trial
Official title:
Motivation and Executive Control in Schizophrenia
Verified date | April 2018 |
Source | Hôpital le Vinatier |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In order to control a behaviour, investigators need to realise goal directed actions and to
priories some actions. This control is required in unusual situation. Appropriate actions are
selected and coordinated according to context and aim.
Several studies try to draw a model of executive function. Recently, Koechlin has suggested a
three levelled organisation to explain how the prefrontal cortex controls actions.
Contextual control is useful to answer appropriately with the immediate context. Episodic
control allows selecting the action according to specific information given before. Sensorial
control is the automatic response when a stimulus is presented.
Some diseases like schizophrenia are associated with neurological dysfunction in prefrontal
cortex. Chambon and al (2008) have identified a dysfunction of contextual control in
schizophrenia.
As the prefrontal cortex is involved in motivational process, it seems interesting to study
potential links between executive function and motivation. A study from Kouneiher shows
contextual and episodic activation of motivation in healthy population.
Investigators aim to study the way motivational process are recruited in schizophrenia.
Status | Completed |
Enrollment | 41 |
Est. completion date | April 24, 2018 |
Est. primary completion date | April 24, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 45 Years |
Eligibility |
Inclusion Criteria: - Age 18-45 years old - schizophrenia - french native speaker Exclusion Criteria: - Neurological disease - Motor or visual deficit - Somatic treatment with neurological impact - Drug abuse |
Country | Name | City | State |
---|---|---|---|
France | Professeur FRANCK Nicolas | Bron | Rhone-alpes |
Lead Sponsor | Collaborator |
---|---|
Hôpital le Vinatier |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | reaction time | reaction time is recorded when the subject press the key (subject should press a key function of the characteristics of the letter submitted)Reaction time should vary with the level of executive control (episodic, contextual, and motivation control (episodic or contextual motivation). Responses will be compared across patients and control. | 24 hours |
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