Clinical Trials Logo
  1. Home
  2. Schizophrenia
  3. NCT02455193
  4. Details
NCT02455193 Clinical Trial

Neuronal Effects of Exercise in Schizophrenia

Schizophrenia Clinical Trial

Official title:
Neuronal Effects of Exercise in Schizophrenia

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT02455193
Other study ID # 14-1282
Secondary ID UL1TR001082R01MH
Status Recruiting
Phase N/A
First received
Last updated
Start date August 2014
Est. completion date July 2025

Study information
Verified date February 2024
Source University of Colorado, Denver
Contact Kristina T Legget, Ph.D.
Phone 303-724-5809
Email kristina.legget@ucdenver.edu
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study plans to learn more about how common drugs prescribed to individuals with schizophrenia contribute to weight gain, as well as how exercise and diet impact appetite and the brain's response to food. In this study, the investigators will be evaluating how participants' brains respond to food images as well as asking questions about their food preferences and intake and clinical symptoms. The investigators may also ask participants to complete an exercise or diet intervention to see how this changes brain responses or food preferences.

Recruitment information / eligibility
Status Recruiting
Enrollment 140
Est. completion date July 2025
Est. primary completion date July 2025
Accepts healthy volunteers No
Gender All
Age group 21 Years to 70 Years
Eligibility Inclusion Criteria: - Diagnosis of schizophrenia or schizoaffective disorder - Between 21 and 70 years of age - Currently prescribed either olanzapine, risperidone, clozapine, or haloperidol, OR not currently being treated with any neuroleptic medications - Weight stable within 5 percent for the last 6 months Exclusion Criteria: - Pregnancy - Substance abuse - Significant endocrine/metabolic disease (e.g., uncontrolled hypertension, severe hypertriglyceridemia) - MRI-specific exclusion criteria (e.g., claustrophobia, metal in the body)

Study Design

Related Conditions & MeSH terms

Intervention

Behavioral:
• Exercise

• Diet

Locations
Country Name City State
United States University of Colorado Anschutz Medical Campus Aurora Colorado

Sponsors (3)
Lead Sponsor Collaborator
University of Colorado, Denver National Center for Advancing Translational Sciences (NCATS), National Institute of Mental Health (NIMH)

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Neuronal response to visual food cues Neuronal response (insula) while viewing visual food cues 14 weeks
Primary Resting-state neuronal response Neuronal response (default mode network) during rest 14 weeks
Secondary Appetite Rating on a visual analogue scale (VAS) Participants will be asked to rate their hunger via Hunger ratings on a VAS 14 weeks
Secondary Fasting leptin Fasting blood levels of leptin 14 weeks
Secondary Fasting ghrelin Fasting blood levels of ghrelin 14 weeks
See also
  Status Clinical Trial Phase
Recruiting NCT05039489 - A Study on the Brain Mechanism of cTBS in Improving Medication-resistant Auditory Hallucinations in Schizophrenia N/A
Completed NCT05321602 - Study to Evaluate the PK Profiles of LY03010 in Patients With Schizophrenia or Schizoaffective Disorder Phase 1
Completed NCT05111548 - Brain Stimulation and Cognitive Training - Efficacy N/A
Completed NCT04503954 - Efficacy of Chronic Disease Self-management Program in People With Schizophrenia N/A
Completed NCT02831231 - Pilot Study Comparing Effects of Xanomeline Alone to Xanomeline Plus Trospium Phase 1
Completed NCT05517460 - The Efficacy of Auricular Acupressure on Improving Constipation Among Residents in Community Rehabilitation Center N/A
Completed NCT03652974 - Disturbance of Plasma Cytokine Parameters in Clozapine-Resistant Treatment-Refractory Schizophrenia (CTRS) and Their Association With Combination Therapy Phase 4
Recruiting NCT04012684 - rTMS on Mismatch Negativity of Schizophrenia N/A
Recruiting NCT04481217 - Cognitive Factors Mediating the Relationship Between Childhood Trauma and Auditory Hallucinations in Schizophrenia N/A
Completed NCT00212784 - Efficacy and Safety of Asenapine Using an Active Control in Subjects With Schizophrenia or Schizoaffective Disorder (25517)(P05935) Phase 3
Completed NCT04092686 - A Clinical Trial That Will Study the Efficacy and Safety of an Investigational Drug in Acutely Psychotic People With Schizophrenia Phase 3
Completed NCT01914393 - Pediatric Open-Label Extension Study Phase 3
Recruiting NCT03790345 - Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics Phase 2/Phase 3
Recruiting NCT05956327 - Insight Into Hippocampal Neuroplasticity in Schizophrenia by Investigating Molecular Pathways During Physical Training N/A
Terminated NCT03261817 - A Controlled Study With Remote Web-based Adapted Physical Activity (e-APA) in Psychotic Disorders N/A
Terminated NCT03209778 - Involuntary Memories Investigation in Schizophrenia N/A
Completed NCT02905604 - Magnetic Stimulation of the Brain in Schizophrenia or Depression N/A
Recruiting NCT05542212 - Intra-cortical Inhibition and Cognitive Deficits in Schizophrenia N/A
Completed NCT04411979 - Effects of 12 Weeks Walking on Cognitive Function in Schizophrenia N/A
Terminated NCT03220438 - TMS Enhancement of Visual Plasticity in Schizophrenia N/A