Schizophrenia Clinical Trial
Official title:
A RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, PARALLEL GROUP, SPONSOR OPEN, PHASE 1B STUDY TO EXAMINE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF PF-06412562 IN PSYCHIATRICALLY STABLE SUBJECTS WITH SCHIZOPHRENIA
This study is designed to investigate the safety, tolerability pharmacokinetics and pharmacodynamic effects of PF-06412562 following multiple dose administration as MR tablets in subjects with schizophrenia.
B7441007 is a randomized, double-blind, placebo-controlled, sponsor open, parallel group
design, Phase 1b study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of
3 doses of PF-06412562 (3 mg BID, 9 mg BID and 45 mg BID) over 15 days in approximately 100
psychiatrically stable (as defined by the inclusion and exclusion criteria) subjects with
schizophrenia are on background treatment with SOC antipsychotics and other psychotropic
medications.
All doses will be administered twice daily, with approximately 12 hours between each dose.
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