Schizophrenia Clinical Trial
Official title:
Evaluation of an Intervention Program Designed to Improve Understanding of Irony on the Hemispheric Processing of Ambiguous Figurative Language in Adults With Schizophrenia
Intervention aimed at improving understanding of irony in social situations by using movies and comic strip will improve theory of mind.
The overreaching goal of this study is to examine the influence of short CBT of irony
comprehension on hemispheric involvement of adults with Schizophrenia. To obtain this goal a
three phase study have been designed.
In the first phase all participants will be asked to fill out questionnaires screening for,
cognitive abilities (TONI-3 third edition), vocabulary (Hebrew adaptation of Wechsler Adult
Intelligence Scale-Third Edition, WAIS 3 HEB, Wechsler 1997), executive function
capabilities and figurative language understanding (irony and metaphor) .Theory of Mind
comprehension will also be assessed by using The Hinting Test (Corcoran et al.1995).
Hemispheric processing will be examined by two behavioral hemispheric experiments using
split visual field paradigm. The subject sits in front of a computer screen, reads a prime
sentence, and reacts to a lateralized target word.
In the first experiment- Idioms experiment, the target word in each trail would be related
to the meaning of a preceding prime idiom or associated to its literal meaning .The
participant is instructed to indicate as rapidly and accurately as possible whether the
target word stimulus is a meaningful word or non- word. In the second experiment- irony
experiment, the target word in each trail would be a literal, ironic or unrelated ending to
the preceding prime sentence .Subjects would be asked to relate to the target word and to
indicate as rapidly and accurately as possible whether the target word stimulus formed a
meaningful expression with the preceding prime. Stimulus presentation and response would be
controlled and recorded by Super-Lab 4.5 software.
The first phase will be carried out in 1-2 sessions.
In the second phase subjects will participate in a social intervention program for
comprehension of verbal irony. Over the course of intervention participants will analyze and
discuss short film scenario's that end with an ironic statement, and will experience
completing short scenario's that contain irony. Intervention will include 5 sessions, 3-5
subjects will participate in each group.
In the third phase participants will undergo the Irony behavioral hemispheric experiment to
examine changes in hemispheric processing when exposed to irony after treatment, the irony
and metaphor questioners and the Hinting test. This phase will be carried out in one
session.
35 subjects will participate in the study, 20 in the study group and 15 in the control
group.
Subjects in the control group will watch the short film scenario's that end with an ironic
statement and rank each video for its comprehensibility and their level of enjoyment.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care
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