Schizophrenia Clinical Trial
— CASTOfficial title:
Optimizing Cognitive Remediation Outcomes in Schizophrenia
NCT number | NCT02105779 |
Other study ID # | R01MH082818 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | December 2009 |
Est. completion date | July 26, 2016 |
Verified date | April 2019 |
Source | University of California, San Francisco |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to drive an optimal response to neuroplasticity-based cognitive remediation in schizophrenia in order to maximize treatment response. The investigators will investigate factors that have generally been ignored in prior computer-based cognitive remediation programs—those related to social cognition-- and will delineate their relationship to motivation, functional outcome, and the neural substrates of reward anticipation and emotion processing. Current research indicates that, unless the investigators fully understand and harness these factors, the investigators will not achieve meaningful treatment gains for individuals with schizophrenia.
Status | Completed |
Enrollment | 172 |
Est. completion date | July 26, 2016 |
Est. primary completion date | May 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Clinical diagnosis of schizophrenia or schizoaffective disorder - Between 18-65 years of age - Clinically stable - Fluent in English Exclusion Criteria: - Recent hospitalization, in the past 3 months - History of traumatic brain injury - Neurological disorders - Inability to participate in the study soberly |
Country | Name | City | State |
---|---|---|---|
United States | San Francisco Veterans Medical Center | San Francisco | California |
Lead Sponsor | Collaborator |
---|---|
University of California, San Francisco |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change from Baseline Social Cognition at 6 months | Social functioning scale | Baseline (Intake)/6 months follow-up after trianing completion |
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