Cerebral Reorganization in Schizophrenia

Schizophrenia Clinical Trial

Official title:

Training-induced Cerebral Reorganization in Schizophrenia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01781000
• Other study ID #: RO805/142
• Status: Completed
• Phase: N/A
• First received: January 22, 2013
• Last updated: November 3, 2014
• Start date: December 2011
• Est. completion date: April 2014

Study information

• Verified date: November 2014
• Source: University of Konstanz
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: Ethics Commission
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to reveal the specific effects of computer-aided cognitive training on cerebral reorganization in schizophrenia

Description:

Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease. In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing. The other training focus on facial affect discrimination and working memory. Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: April 2014
• Est. primary completion date: April 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Clinical diagnosis of schizophrenia and disorders with psychotic features

• Intact auditory perception

• Intact visual perception

Exclusion Criteria:

• Mental retardation

• Age over 60

• Insufficient German language knowledge

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Schizophrenia

Intervention

Behavioral:
• Brain Fitness & Brain Training- Posit Science
Computer aided cognitive program designed for intensive training of auditory perception, memory and attention
• Facial Affect Training- FAT
Computer-aided cognitive program designed for intensive training of facial affect discrimination, memory and attention
• Treatment as usual
standard treatment protocol of schizophrenia ward

Locations

Country	Name	City	State
Germany	University of Konstanz	Konstanz	Baden Württemberg

Sponsors (1)

Lead Sponsor	Collaborator
University of Konstanz

Country where clinical trial is conducted

Germany, 

References & Publications (1)

Popova P, Popov TG, Wienbruch C, Carolus AM, Miller GA, Rockstroh BS. Changing facial affect recognition in schizophrenia: effects of training on brain dynamics. Neuroimage Clin. 2014 Sep 4;6:156-65. doi: 10.1016/j.nicl.2014.08.026. eCollection 2014. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	change from baseline at post-intervention (4-weeks) and 3-months in each to the primary outcome measures: neuropsychological test scores (MCCB), MEG alpha oscillations		baseline, post-intervention (after 4 weeks), 3-months follow-up	No
Secondary	change from baseline in global functioning (GAF score) at 4 weeks and 3 months		baseline, post-intervention, 3-months follow-up	No

External Links

•   Brain Training Software