Schizophrenia Clinical Trial
Official title:
Therapeutic Efficacy of Cerebellar Repetitive Transcranial Magnetic Stimulation in Patients With Schizophrenia
The aim of this study is to look at the effectiveness of repetitive transcranial magnetic stimulation (rTMS) as a therapeutic intervention for patients with schizophrenia. The primary outcome is improvement in negative symptoms related to schizophrenia. The investigators are focusing on negative symptoms given their greater resistance to pharmacological and other established therapies. If the investigators trial were to show beneficial effects, its clinical significance would be great.
This study builds on the results of a previous phase 1, single-site study in which we
demonstrated the safety of image-guided theta burst stimulation (TBS) form of rTMS over the
cerebellar vermis (Demirtas-Tatlidede et al., 2010) in eigh patients with schizophrenia.
The primary goal of the present study is to assess efficacy of iTBS to the cerebellar vermis
on positive and negative symptoms of schizophrenia. A second, added goal is to investigate
the mechanisms of the expected clinical improvement.
Schizophrenia is a leading cause of mental disability and current treatments still remain
only partially successful for many patients. Our underlying hypothesis is that modulation of
the cerebellar vermis may enhance activity of the neural systems that sub-serve cognition and
emotion, reestablish the disturbed cerebellar regulation in schizophrenic patients, and
produce clinical improvement.
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