Schizophrenia Clinical Trial
Official title:
Mitochondria and Schizophrenia: Effects of Antipsychotic Drugs
The investigators will investigate
1. the relationships between oxidative stress-, apoptosis-related markers, mitochondria
DNA copy numbers and the clinical psychopathology of schizophrenia, including severity
of positive and negative symptoms, obesity and metabolic syndrome.
2. the relationships between aberrant mitochondria genes (single nucleotide polymorphism
of D-loop region-related genes and haplogroup N9a), DISC1 gene polymorphism, and
clinical phenotypes in Taiwanese populations.
3. whether these biological markers could be as clinical markers in schizophrenia for a
long-term follow-up study.
In past study, we had shown that there were significant differences in serum Lpo (lipid
peroxidation) and Thiol levels between patients with schizophrenia and healthy controls. For
patients taking risperidone, there were significant decreases in serum Thiol levels. In
addition, there were also significant differences in age of onset of PPAR gamma coactivator
1α (PGC-1α) polymorphism for schizophrenia patients. Therefore, we want to know the
relationships between oxidative stress-, apoptosis-related markers, mitochondria DNA copy
numbers and the clinical psychopathology of schizophrenia, including severity of positive
and negative symptoms, obesity and metabolic syndrome.
In past study, we also found that there were significant differences in 10 SNPs located in
the D-loop region-related genes between patients and healthy controls. Three SNPs could be
found in Mitomap data, but another seven SNPs not been found in the Mitomap and they could
be more confirmed. In addition, Tanaka et al. found that haplogroup N9a was related to
diabetes and metabolic syndrome in Asia. Therefore, we were interested to clarify the
relationships between above related mitochondria genes and clinical phenotypes in Taiwanese
populations,.
In addition, we also want to see whether these biological markers could be as clinical
markers in schizophrenia for a long-term follow-up study.
;
Observational Model: Case-Only, Time Perspective: Prospective
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