Schizophrenia Clinical Trial
Official title:
Default Network Dysfunction Underlying Visuospatial Attention Deficits in Schizophrenia
Verified date | December 24, 2014 |
Source | National Institutes of Health Clinical Center (CC) |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Background:
- A special brain circuit is important for helping us keeping an eye open for things that are
going on around us, even when we are not directly paying attention to them. This circuit
seems to work differently in people with schizophrenia than in other people, which may
explain specific deficits with broad monitoring observed in people with schizophrenia.
Researchers want to compare brain function in people with schizophrenia and healthy
volunteers to find out more about how these brain circuits work and affect attention.
Objectives:
- To study how the brain performs broad visual monitoring in people with schizophrenia.
Eligibility:
- Individuals between 18 to 55 years of age who have been diagnosed with schizophrenia.
- Healthy volunteers between 18 and 55.
Design:
- Participants will be screened with physical and psychological exams. They will have a
medical history. Tests for drug and alcohol use will also be done.
- Participants will have two study visits. The first is a training visit and the second is
a scanning visit.
- At the training visit, participants will practice computer-based tests of focus, memory,
and concentration. They will also answer questions about mood, psychiatric symptoms, and
smoking habits.
- At the scanning visit, participants will perform the computer-based tasks that they
practiced at the training visit. They will have magnetic resonance imaging while they
perform these tasks.
Status | Completed |
Enrollment | 64 |
Est. completion date | December 24, 2014 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 55 Years |
Eligibility |
- INCLUSION CRITERIA: All participants: 1. Age 18 through 55. 2. Normal or corrected to normal visual acuity (at least 20/80) Participants with menat illness: 3. DSM-IV diagnosis of schizophrenia or schizoaffective disorder 4. Ability to give written informed consent 5. Four week of stable pharmacological treatment (same psychiatric medication at same dose or no medication) EXCLUSION CRITERIA: All participants: 1. Presence of ferromagnetic metal objects in the body, implanted electronic devices or any other counter -indication for MRI. 2. Claustrophobia 3. Left handed or ambidextrous 4. History of myocardial infarction or heart failur, which may cause asymptomatic brain lesions 5. Uncontrolled high blood pressure (resting systolic greater than 150 or diastolic greater than 90 mm Hg) 6. Neurological conditions likely to impair cognitive function such as stroke, seizures, dementia or organic brian syndrome 7. Any condition likely to impair cognitive function such as mental retardation or severe pharmacological sedation 8. Current use of vasodilating beta-blockers (carvedilol, labetalol or nebivolol) 9. Alcohol or substance abuse or dependence other than nicotine within the last 6 months 10. Pregnancy, verified by urin pregnancy test for females during screening and on the day of the scan. Healthy Controls: 11. Current psychiatric Axis I disorder or Axis II schizophrenia spectrum disorder, verified by Structured Clinical Interview for DSM-IV (SCID) |
Country | Name | City | State |
---|---|---|---|
United States | Maryland Psychiatric Research Center (MPRC) 55 Wade Avenue | Catonsville | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute on Drug Abuse (NIDA) |
United States,
Binder JR, Frost JA, Hammeke TA, Bellgowan PS, Rao SM, Cox RW. Conceptual processing during the conscious resting state. A functional MRI study. J Cogn Neurosci. 1999 Jan;11(1):80-95. — View Citation
Buckner RL, Andrews-Hanna JR, Schacter DL. The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci. 2008 Mar;1124:1-38. doi: 10.1196/annals.1440.011. Review. — View Citation
Bustillo JR, Thaker G, Buchanan RW, Moran M, Kirkpatrick B, Carpenter WT Jr. Visual information-processing impairments in deficit and nondeficit schizophrenia. Am J Psychiatry. 1997 May;154(5):647-54. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Behavioral performance measures on the cognitive tasks (e.g. reaction time, accuracy) | |||
Primary | Bold signal, specifically activation of the default network of resting brain function and its association with task performance. | |||
Secondary | Secondary outcome measures include ratings and scores on questionnaires and characterization tools. |
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