Schizophrenia Clinical Trial
Official title:
A Single-blind, Randomised, Placebo-controlled, Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of GSK1144814 in Healthy Male and Female Subjects and an Open-label Positron Emission Tomography Study in Healthy Male Subjects to Evaluate the Neurokinin-1 (NK1) Receptor Occupancy of GSK1144814 in the Living Human Brain Using 11C GR205171.
This study described in the present protocol consists of two sections. Part A is the first administration into man to evaluate the safety, tolerability and pharmacokinetics of single ascending doses of GSK1144814. The study is a single-blind, randomised, placebo-controlled design in healthy male and female (of non-childbearing potential) subjects. Part B will be an open-label design in healthy male subjects to assess the GSK1144814 neurokinin-1 (NK1) receptor occupancy by positron emission tomography (PET) scanning with [11C]-GR205171
GSK1144814 is a dual neurokinin-1 (NK1) and neurokinin-3 (NK3) antagonist with the potential
to treat schizophrenia & depression.
This study described in the present protocol consists of two sections. Part A is the first
administration into man to evaluate the safety, tolerability and pharmacokinetics of single
ascending doses of GSK1144814. The study is a single-blind, randomised, placebo-controlled
design in healthy male and female (of non-childbearing potential) subjects. Part B will be an
open-label design in healthy male subjects to assess the GSK1144814 NK1 receptor occupancy by
positron emission tomography (PET) scanning with [11C]-GR205171.
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