Schizophrenia Clinical Trial
Official title:
Clozapine and Olanzapine in the Treatment of Violence in Schizophrenic Patients
This was a double-blind randomized study with three treatment arms: clozapine, olanzapine and haloperidol. We compared these three medications in the treatment of aggressive behavior over a 12 week period.
Objective: The purpose of our study was the investigation of the effect of atypical
antipsychotic agents on interpersonal violence and aggression.
We compared the efficacy of two atypical antipsychotic agents, clozapine and olanzapine with
one another and with haloperidol in the treatment of physical assaults and other assaultive
behaviors in physically assaultive patients with schizophrenia and schizoaffective disorder.
Method: The subjects were 110 physically assaultive inpatients diagnosed with schizophrenia
or schizoaffective disorder.
They were randomly assigned to treatment with clozapine (N=37), olanzapine (N=37) or
haloperidol (N=36) in a 12-week, double-blind trial. Incidents of overt aggression were
recorded and their severity was scored with the Modified Overt Aggression Scale (MOAS).
Psychiatric symptoms were assessed through the Positive and Negative Syndrome Scale (PANSS).
We also assessed various side effects and monitored vital signs and drew bloods.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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