Schizophrenia Clinical Trial
Official title:
Efficacy of Hierarchized Computer-assisted Cognitive Remediation Therapy in Schizophrenia
Objectives:
The purpose of this study is to determine the impact of a new Cognitive Remediation Therapy
(CRT) on cognition, social autonomy, symptoms and brain functioning in patients with
schizophrenia.
Methods:
In a 2 arms blind study versus sham,80 patients with schizophrenia were enrolled in a
program consisting of 14 training sessions of 4 cognitive functions
(attention/concentration, topological memory, logical reasoning, executive functions)by
means REHACOM® software. Measures of cognitive functioning using the Cogtest® battery as
well as social autonomy (Social Autonomy Scale, EAS) and schizophrenia symptoms (Positive
And Negative Syndrome Scale, PANSS) were undertaken at the beginning and the end of the
meetings of remediation.
Among those 80 participants, 30 patients to (15 active / 15 sham) were randomized to
participate in an fMRI study in order to investigate the impact of such CRT program on brain
functioning (n-back task before CRT and 3 months later).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Supportive Care
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