Schizophrenia Clinical Trial
The purpose of the study is to evaluate tolerability and efficacy of escitalopram (Cipralex)
treatment in doses beyond 20mg (20-40 mg/d) in patients with OCD and schizophrenia, non
responsive or partially responsive to recommended doses (evaluation according to Y-BOCS).
An open label, prospective study. The study will include 20 patients recruited from the
inpatient wards and from the outpatient clinic who have a DSM-IV diagnosis of schizophrenia
or schizoaffective disorder and OCD.
Before entering the study all patients will be interviewed by 2 senior board certified
psychiatrists in order to confirm the diagnosis of schizophrenia or schizoaffective disorder
and OCD according to DSM-IV criteria.
After confirming the diagnosis of schizophrenia/schizoaffective disorder and OCD each
patient will be evaluated by PANSS, Y-BOCS and GCI-S scales. Those patients who score above
12 points on the Y-BOCS will be eligible for the study.
Rating scales (PANSS, Y-BOCS, CGI-S, CGI-I) will be completed on a weekly basis during the
whole 13 weeks period. In addition patients will be asked to report medication side effects
and will also be clinically evaluated for side effects by the physician. Special attention
will be paid to worsening of psychosis or OC symptoms. All patients whose mental status will
deteriorate or those who cannot tolerate the drug will be dropped-out and intent to treat
analysis will be made.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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