Schizophrenia Clinical Trial
Official title:
A 24-Week, Multicenter, Double-Blind, Randomized, Parallel-Group, Dose Ranging Study of the Efficacy and Safety of 3 Oral Doses of AVE1625 and Placebo on Top of Either Olanzapine, Risperidone/Paliperidone, Quetiapine or Aripiprazole in the Treatment of Cognitive Impairment in Schizophrenia.
AVE1625 is a new potent and selective cannabinoid 1 (CB1) antagonist in clinical development
for the treatment of cognitive impairment in patients diagnosed with schizophrenia.
The main objective of this study is to evaluate the efficacy on cognitive impairment of 3
doses of AVE1625 using a new cognitive battery called MATRICS (Measurement and Treatment
Research to Improve Cognition in Schizophrenia) in schizophrenic patients.
The secondary objectives are to measure the efficacy of AVE1625 on functional capacity of
the patients using a specific scale called UPSA2 (University of California San Diego
Performance-based Skills Assessment 2) and to assess the safety of the compound.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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