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Role of Topical Vancomycin in Reducing Infections in Hip and Knee Arthroplasty

Rheumatoid Arthritis Clinical Trial

Official title:
Can Topical Vancomycin Prevent Periprosthetic Joint Infection in Primary Hip and Knee Arthroplasty? Multicenter Randomized Controlled Trial

Clinical Trial Summary

The study is designed to assess the efficacy of vancomycin powder and dilute povidone-iodine lavage (VIP protocol) in reducing the PJI after primary Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA). We hypothesized that VIP protocol provides superior reduction of periprosthetic joint infection (PJI) rates after primary THA and TKA compared with diluted povidone-iodine (PI) protocol.

Clinical Trial Description

Patients who undergo primary hip or knee arthroplasty, before closure 0,35% povidone-iodine (17,5mL in 500 mL saline) solution lavage left for 3 minutes following final implantation. Patients drawn by random numbers calculator will be administered with 1.0 g Vancomycin powder into the wound around the prosthesis and no suction will be used. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05972603
Study type Interventional
Source Independent Public Healthcare Center in Rypin
Contact
Status Recruiting
Phase N/A
Start date July 1, 2022
Completion date December 2024
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