Physiologic Changes of Posterior Ocular Segment During the Menstrual Cycle

Status Recruiting

Clinical Trial Summary

Changes of luteinizing hormone (LH), estrogen and progesterone during the menstrual cycle influence the ocular physiology in both anterior and posterior segments. From the literature review, there were no significant differentiation in tear physiology, anterior chamber dept, lens thickness and refractive status. Some studies demonstrated then the central corneal thickness was thinner in the follicular phase, but this is non-conclusive. Advance in ophthalmic technologies provide few studies of posterior segment changes during the menstrual cycle, however, there were quite difference in methodology such as detection methods of ovulation.

Clinical Trial Description

There were 2 studies of posterior segment changes during the menstrual cycle. Akar et al showed significant decrease of neuroretinal rim area and increase of cupt area in late luteal phase. Ulas et al found that choroidal thickness was significant thicker in mid-luteal phase. However, the study of retinal vascular density by optical coherence tomography angiography (OCTA) during the menstrual cycle has never been published before. ;

Study Design

Related Conditions & MeSH terms

Retinal Vascular

Clinical Trial Details

NCT number	NCT04731207
Study type	Interventional
Source	Khon Kaen University
Contact	Suthasinee Sinawat, MD
Phone	+66 81 5454594
Email	ssuthasinee@kku.ac.th
Status	Recruiting
Phase	N/A
Start date	September 3, 2021
Completion date	December 30, 2023

View Details

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