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Retinal Detachment clinical trials

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NCT ID: NCT04620876 Recruiting - Stroke Clinical Trials

Bimodal and Coaxial High Resolution Ophtalmic Imaging

AOSLO-OCT
Start date: October 1, 2019
Phase: N/A
Study type: Interventional

The knowledge of the pathogenesis of retinal affections, a major cause of blindness, has greatly benefited from recent advances in retinal imaging. However, optical aberrations of the ocular media limit the resolution that can be achieved by current techniques. The use of an adaptive optics system improves the resolution of ophthalmoscopes by several orders of magnitude, allowing the visualization of many retinal microstructures: photoreceptors, vessels, bundles of nerve fibers. Recently, the development of the coupling of the two main imaging techniques, the Adaptive Optics Ophthalmoscope with Optical Coherence Tomography, enables unparalleled three-dimensional in vivo cell-scale imaging, while remaining comfortable for the patients. The purpose of this project is to evaluate the performance of this system for imaging micrometric retinal structures.

NCT ID: NCT04580147 Recruiting - Clinical trials for Proliferative Vitreoretinopathy

Intravitreal Aflibercept for the Prevention of Proliferative Vitreoretinopathy Following Retinal Detachment Repair

PREVENT-PVR
Start date: October 15, 2020
Phase: Phase 2
Study type: Interventional

The primary objective of the study is to determine if serial intravitreal aflibercept injections (IAI) improve the single surgery anatomic success rate following surgical repair of primary, macula involving rhegmatogenous retinal detachment (RRD) deemed at high risk for proliferative vitreoretinopathy (PVR). Preclinical work has revealed that competitive inhibition of platelet derived growth factor (PDGF) by vascular endothelial growth factor (VEGF) potentiates a pathologic, sustained activation of PDGF receptors that is critical to the progression of experimental PVR. VEGF blockade would mitigate this pathologic activation.

NCT ID: NCT04571788 Recruiting - Surgery Clinical Trials

Treating Rhegmatogenous Retinal Detachment by Foldable Capsular Buckle

Start date: September 1, 2019
Phase:
Study type: Observational [Patient Registry]

To evaluate the efficacy and safety of treating rhegmatogenous retinal detachment (RRD) using foldable capsular buckle (FCB). It is a multi-center clinical ,randomized, controlled, and single-blind clinical study.

NCT ID: NCT04557527 Recruiting - Clinical trials for Retinal Detachment With Break

Suprachoroidal Visco-buckling for the Treatment of Rhegmatogenous Retinal Detachment

VIKING
Start date: February 7, 2022
Phase: N/A
Study type: Interventional

The study compares standard surgery for retinal detachment (RD) (vitrectomy, cryotherapy and gas) with a surgical variation that replaces the intraocular gas tamponade with suprachoroidal injection of viscoelastic underneath the break that caused the retinal detachment.

NCT ID: NCT04404296 Recruiting - Retinal Detachment Clinical Trials

Pars Plana Vitrectomy With 25-gauge 20000 Cpm, Bevel-tip Cutter

HYPE
Start date: April 1, 2021
Phase: N/A
Study type: Interventional

Report efficiency and clinical outcomes using 25-gauge, bevel-tip, 20000 cut per minute vitrectomy probe among eyes with various vitreo-retinal diseases

NCT ID: NCT04403750 Recruiting - Clinical trials for Rhegmatogenous Retinal Detachment

Combined Laser-surgical Technology of RRD Treatment

Start date: September 15, 2018
Phase: N/A
Study type: Interventional

Purpose: to assess the efficacy and safety of combined laser-surgical technology of RRD treatment

NCT ID: NCT04158622 Recruiting - Retinal Detachment Clinical Trials

Retinal Displacement Rates in Pneumatic Retinopexy Versus Pars Plana Vitrectomy For Primary Retinal Detachment

REVEAL
Start date: March 15, 2021
Phase: N/A
Study type: Interventional

Patients may experience metamorphopsia, or image distortion, after having vitrectomy to repair their rhegmatogenous retinal detachments (RRDs) especially those with a detached macula. Retinal displacement, as measured on autofluorescence photography, likely contributes to this distortion. There is no study in the scientific literature comparing the rate of retinal displacement and its association with visual function, including metamorphopsia, in patients undergoing different procedures for RRD repair. Based on the recently published PIVOT trial, patients who underwent Pneumatic Retinopexy (PnR) had less vertical distortion at 12 months than patients who had Pars Plana Vitrectomy (PPV). It is hypothesized that PnR will cause less retinal displacement than PPV for patients with macula-off primary retinal detachment.

NCT ID: NCT04129021 Recruiting - Stroke Clinical Trials

Multimodal Ophthalmic Imaging

IMA-MODE
Start date: July 15, 2019
Phase: N/A
Study type: Interventional

Knowledge of the pathogenesis of ocular conditions, a leading cause of blindness, has benefited greatly from recent advances in ophthalmic imaging. However, current clinical imaging systems are limited in resolution, speed, or access to certain structures of the eye. The use of a high-resolution imaging system improves the resolution of ophthalmoscopes by several orders of magnitude, allowing the visualization of many microstructures of the eye: photoreceptors, vessels, nerve bundles in the retina, cells and nerves in the cornea. The use of a high-speed acquisition imaging system makes it possible to detect functional measurements such as the speed of blood flow. The combination of data from multiple imaging systems to obtain multimodal information is of great importance for improving the understanding of structural changes in the eye during a disease. The purpose of this project is to observe structures that are not detectable with routinely used systems.

NCT ID: NCT04082962 Recruiting - Clinical trials for Exudative Retinal Detachment and Uveal Melanoma

Dexamethasone Implant for Retinal Detachment in Uveal Melanoma

Start date: April 16, 2018
Phase: Phase 1
Study type: Interventional

This is an investigator-initiated Phase I study of a single dose of an intravitreally-administered dexamethasone implant (Ozurdex™) in subjects with uveal melanomas (UM) and exudative retinal detachments (ERD: build-up of fluid under the retina that causes it to detach) being treated with proton beam radiation (PBI) or plaque radiotherapy. Although PBI is an effective treatment for UM, ERDs may persist after radiation, leading to vision loss. Effective treatments for ERD are currently lacking. We are conducting this study to evaluate whether Ozurdex™ can help resolve ERDs that occur in patients with UM. Ozurdex™ has been approved by the Food and Drug Administration (FDA) to treat certain ocular conditions such as macular edema, non-infectious uveitis, and diabetic macular edema but it is not approved for use in patients with UM and ERD. This study will determine the safety of the dexamethasone implant and provide preliminary evidence of efficacy in this population.

NCT ID: NCT04035343 Recruiting - Retinal Detachment Clinical Trials

Effect of Type of Head Positioning on Retinal Displacement in Vitrectomy for Retinal Detachment

DIAMOND
Start date: August 26, 2019
Phase: N/A
Study type: Interventional

Patients may experience metamorphopsia, or image distortion, after having vitrectomy to repair their rhegmatogenous retinal detachments especially those with a detached macula. Retinal displacement, as measured on autofluorescence photography, likely contributes to this distortion. It is thought that the retina slips inferiorly due to the residual subretinal fluid shifting as the patient transitions from the supine position intraoperatively to the sitting up position in the immediate postoperative period. By having the patient immediate position facedown or according to the retinal break, the risk of slippage is theoretically decreased.