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Retinal Degeneration clinical trials

View clinical trials related to Retinal Degeneration.

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NCT ID: NCT04945772 Completed - Clinical trials for Retinitis Pigmentosa

Efficacy and Safety of MCO-010 Optogenetic Therapy in Adults With Retinitis Pigmentosa [RESTORE]

RESTORE
Start date: July 13, 2021
Phase: Phase 2
Study type: Interventional

The purpose of the study is to evaluate the safety and efficacy of a single intravitreal injection of virally-carried Multi-Characteristic Opsin (MCO-010).

NCT ID: NCT04919473 Completed - Clinical trials for Retinitis Pigmentosa

Dose-Escalation Study to Evaluate the Safety and Tolerability of Intravitreal vMCO-I in Patients With Advanced Retinitis Pigmentosa

Start date: October 23, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of the study is to evaluate the safety and tolerability of a single intravitreal injection of virally-carried Multi-Characteristic Opsin I (vMCO-I)

NCT ID: NCT04246866 Completed - Clinical trials for Macular Degeneration

First in Human Study to Evaluate the Safety and Tolerability of GEM103 in Geographic Atrophy Secondary to Dry Age Related Macular Degeneration

Start date: December 19, 2019
Phase: Phase 1
Study type: Interventional

The study is designed to identify the maximum tolerated dose (MTD) for intravitreal (IVT) administration of GEM103 in subjects with geographic atrophy (GA) secondary to dry AMD. Safety and tolerability of a single dose of GEM103 will be assessed based on the occurrence of dose-limiting toxicities (DLTs). Each subject will be followed for safety, pharmacokinetic (PK), clinical, and biomarker evaluations. Three escalating dose cohorts are planned.

NCT ID: NCT04115917 Completed - Retinal Detachment Clinical Trials

Evaluation of Discomfort Associated With Scleral Depression During Retina Examinations

DEPRESS
Start date: January 1, 2018
Phase: N/A
Study type: Interventional

Scleral depression is an important technique used to examine the peripheral retina but often causes patient discomfort. The goal of this study was to compare levels of discomfort during scleral depression with a Schocket scleral depressor and cotton tipped applicator.

NCT ID: NCT03954626 Completed - Clinical trials for Age-Related Macular Degeneration

Study to Collect Safety and ECG Data on Brolucizumab 6 mg Intravitreal Treatment in Patients With Wet AMD

Start date: June 7, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study was to collect ECG data after a single IVT injection of brolucizumab 6 mg in patients with neovascular age-related macular degeneration (nAMD).

NCT ID: NCT03843840 Completed - Clinical trials for Diabetic Retinopathy

Dual Wavelength OCT

Start date: February 15, 2019
Phase:
Study type: Observational

The purpose of this research is the evaluation of a combined coaxial optical coherence tomography (OCT) system to image retina/choroid and to evaluate if post processing of the data can give us insights into property of the tissue imaged.

NCT ID: NCT03492853 Completed - Clinical trials for Peripheral Retinal Degenerations, Age Related Macular Degeneration Polymorphisms

The Association of the Peripheral Retinal Changes and Genotypic Changes in Patients With Age Related Macular Degeneration

Start date: January 1, 2015
Phase:
Study type: Observational [Patient Registry]

Purpose: To examine the genotypes associated with the peripheral retinal phenotypic features in patients with age-related macular degeneration documented with wide-field imaging. Design: Clinic-based case series study in Croatia. Participants: 160 patients >50 years of age known to have early or advanced AMD and 150 subjects >50 years of age without known AMD (controls) Methods: Both groups of patients were examined with ophthalmoscopy and OCT to confirm their classification. Posterior and peripheral fundus features were documented with Optos wide-field imaging (Optos P200MA, Optos Plc, Dunfermline, Scotland) and graded. DNA was extracted from blood samples and gene polymorphisms were evaluated for complement factor H (CFH) rs1061170 and rs1410996, age-related maculopathy susceptibility (ARMS2) rs10490924, high temperature requirement factor A1 (HtrA1) rs11200638, complement factor B (CFB) rs4151667 and rs641153, complement factor 2 (C2) rs9332739 and rs547154 and complement factor 3 (C3) rs2230199.

NCT ID: NCT03396042 Completed - Eye Diseases Clinical Trials

Natural History Study of CEP290-Related Retinal Degeneration

Start date: December 17, 2017
Phase:
Study type: Observational

A prospective natural history study with systematic assessments and uniform follow-up to provide a high-quality dataset for assisting in the design of future clinical treatment trials involving patients with CEP290-related retinal degeneration caused by the common intron 26 mutation.

NCT ID: NCT03321253 Completed - Retinal Detachment Clinical Trials

Changes of Macular Pigment and Parameters of Eyes After YAG Laser Treatment in Cases With Capsule Opacification

Start date: October 23, 2015
Phase: N/A
Study type: Interventional

It has been hypothesized that potential effects of laser Nd: YAG laser posterior capsulotomy may affect macular pigment as well as choroidal thickness, macular thickness and anterior chamber parameters, so it was aimed to investigate possible effects of Nd: YAG laser posterior capsulotomy on macular pigment optical density, choroidal thickness, macular thickness and anterior chamber parameters in cases with posterior capsule opacification in this study.

NCT ID: NCT03318549 Completed - Glaucoma Clinical Trials

BCI and Evaluation of Visual and Task Performance in Subjects With Eye Diseases

Start date: October 29, 2018
Phase: N/A
Study type: Interventional

The purpose of this research study is to better understand the impact of visual impairment caused by different eye diseases on the ability to perform daily activities and compare it to that in patients without eye diseases.