Respiratory Syncytial Virus Infections Clinical Trial
Official title:
The Development of a Human Model of Respiratory Syncytial Virus Infection
The aim of this study is to understand the immune response (how the body fights infection)
to Respiratory Syncytial Virus (RSV). This virus usually causes a simple 'common cold'
illness in healthy adults, but can cause wheezing and lung problems in young infants and the
elderly. The investigators want to understand why this is, in order to develop vaccines and
treatments.
Participants will include 30-40 healthy adults age 18-55 years. Study procedures will
include brief medical exams, breathing tests, a diary of symptoms, blood tests, samples of
fluid (lavage) and cells from the nose, throat and lungs. All participants will receive the
virus via drops in the nose. The duration of the study for all subjects will be 6 weeks.
Bronchiolitis is the commonest cause of hospital admission in infants. It is caused by
Respiratory Syncytial Virus(RSV), a virus that causes mild 'common colds' in adults, but can
cause lung inflammation and difficulty breathing in infants and the elderly. In 2005, nearly
34 million cases in children <5 years occurred, resulting in 3.4 million hospital
admissions,and around 120,000 deaths. There is no vaccine, and some previous vaccines
actually made the disease worse.
The investigators have been trying to understand why for 40 years. Advances in immunology
have given us a completely different way of looking at inflammation: rather than studying
what causes it, the investigators now want to know what regulates it. Much of what the
investigators know about how what causes and regulates inflammation has come from studies of
animals, however, these do not exactly predict what happens in man.
The investigators therefore plan to infect healthy adult volunteers with RSV, and observe
what happens in humans after RSV infection. The investigators will collect samples of blood,
fluid and cells from the nose, throat, and lungs, and a diary of symptoms over four weeks.
The investigators will analyse the blood, fluid, and cells to determine the important
mechanisms that regulate inflammation in human RSV infection.
Studies like this have been conducted previously with no severe side effects. The
investigators anticipate that the discoveries made in this research project will help us
achieve a better understanding of what causes and regulates inflammation in RSV so that the
investigators can learn ways to control it, with the aim of developing vaccines and
treatments.
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Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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