Change of Regional Ventilation During Spontaneous Breathing After Lung

Status Completed

Clinical Trial Summary

Perioperative changes in regional ventilation by pulmonary electrical impedance tomography and spirometry will be investigated in patients at risk for postoperative pulmonary complications. Those patients undergo lung and flail chest surgery.

Clinical Trial Description

Postoperative pulmonary complications (Defined as pulmonary infection, pleural effusion, atelectasis, pneumothorax, bronchospasm, aspiration pneumonitis or respiratory insufficiency subsequent to surgery) increase the morbidity and mortality of surgical patients. Several independent factors determined by the patients' characteristics and the operative procedure increase the risk for those complications. The postoperative decrease of values measured by spirometry, such as the forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), were found in patients after major surgical procedures for several days. The postoperative reduction of those measurement can be the result of general functional limitations in those patients (e.g. by postoperative pain) or the result of a regional postoperative pulmonary complication (e.g. atelectasis, pleural effusion). The method of the electrical impedance tomography (EIT) enables to visualize the regional ventilation within a transversal section of the lung in real time. Studies examining the change of pulmonary EIT for several days postoperatively in spontaneously breathing patients are lacking. The aim of the present study is to examine perioperative changes in regional ventilation in spontaneously breathing patients during their recovery after lung and flail chest surgery. Moreover, the association of those changes with expected changes in spirometry is tested. Finally, in patients with evident postoperative pulmonary complications the value of pulmonary EIT to detect those changes is investigated. The study should improve the knowledge about the development of postoperative pulmonary complications and test the scientific and clinical value of pulmonary EIT in those spontaneously breathing patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02779595
Study type	Observational
Source	Wuerzburg University Hospital
Contact
Status	Completed
Phase	N/A
Start date	June 2016
Completion date	August 2017

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05904652` - High Flow Nasal Oxygen at Extubation for Adults Requiring a Breathing Tube for Treating Severe Breathing Difficulties	N/A
Completed	`NCT04030208` - Evaluating Safety and Efficacy of Umbulizer in Patients Requiring Intermittent Positive Pressure Ventilation	N/A
Recruiting	`NCT03697785` - Weaning Algorithm for Mechanical VEntilation	N/A
Recruiting	`NCT02989051` - Fluid Restriction Keeps Children Dry	Phase 2/Phase 3
Completed	`NCT02930525` - Effect of High Flow Nasal Cannula vs. Standard Care on Respiratory Stability in Pediatric Procedural Sedation	N/A
Recruiting	`NCT02539732` - Prediction of Outcome of Weaning From Mechanical Ventilation Using the Electrical Activity of the Diaphragm
Enrolling by invitation	`NCT02290236` - Monitored Saturation Post-ICU	N/A
Completed	`NCT02056119` - RCT of Mesh Versus Jet Nebulizers on Clinical Outcomes During Mechanical Ventilation in the Intensive Care Unit	N/A
Terminated	`NCT01583088` - Early Stage Amyotrophic Lateral Sclerosis Phrenic Stimulation	Phase 3
Withdrawn	`NCT00990119` - High Flow Therapy (HFT) to Treat Respiratory Insufficiency in Chronic Obstructive Pulmonary Disease (COPD)	N/A
Completed	`NCT01411722` - Electrical Activity of the Diaphragm During the Weaning Period	Phase 2
Completed	`NCT00741949` - Broncho-alveolar Lavage Under Noninvasive Ventilation With Propofol TCI in Patient With AHRF	Phase 3
Recruiting	`NCT00339053` - Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair	Phase 4
Recruiting	`NCT00187434` - Comparison of Two Methods of Continuous Positive Airway Pressure (CPAP) to Support Successful Extubation of Infants of Birth Weights ≤ 1500 Grams (C2CPAP)	N/A
Completed	`NCT02687802` - Respiratory Mechanics and Patient-ventilator Asynchrony Index in Patients With Invasive Mechanical Ventilation
Not yet recruiting	`NCT05906030` - Diaphragm Dysfunction and Ultrasound Perioperatively
Completed	`NCT03850977` - Is There an Association Between Chronic Pancreatitis and Pulmonary Function
Completed	`NCT02845375` - Effect of Neuromuscular Blockade and Reversal on Breathing	Phase 4
Recruiting	`NCT03309423` - Is Venous to Arterial Conversion (v-TAC) of Blood Gas Reliable in Critical Ill Patients in the ICU?	N/A
Completed	`NCT04115969` - Outcome After Non-invasive Ventilation.

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Change of Regional Ventilation During Spontaneous Breathing After Lung Surgery

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms