Respiratory Distress Syndrome Clinical Trial
Official title:
Use of Electrical Impedance Tomography in Children With Syndrome of Acute Respiratory Disorder
Verified date | August 2020 |
Source | Universidade Metodista de Piracicaba |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
INTRODUCTION: Electrical impedance tomography is a tool for noninvasive monitoring of pulmonary ventilation in real time, which is used during alveolar recruitment maneuvers in patients with acute respiratory distress syndrome. OBJECTIVES: To identify ventilatory and hemodynamic changes during the alveolar recruitment maneuver in children with acute respiratory distress syndrome using electrical impedance tomography. METHODS: Twenty children, aged 4 to 12 years, who present a diagnosis of respiratory distress syndrome, with indication of alveolar recruitment admitted to the Pediatric Intensive Care Unit of the Santa Casa de Misericórdia Foundation of Pará will be selected. Data collection will consist of three before the alveolar recruitment maneuver, immediately after the alveolar recruitment maneuver, 2 hours after the alveolar recruitment maneuver, where the pulmonary ventilation distribution, the driving pressure, the real-time reading compliance will be analyzed. tomography of the Timpel brand, autonomic heart rate modulation through the Polar® RS800CX device, physiological variables such as heart rate, oxygen pulse saturation and blood pressure by measuring the DIXTAL multi-parameter monitor, blood oxygen pressure and the oxygen content dog. The statistical analysis will be performed in the Biostat 5.2 program, and the choice of tests will depend on the types of distributions found and the homogeneity of the respective variances.
Status | Completed |
Enrollment | 20 |
Est. completion date | December 31, 2019 |
Est. primary completion date | December 31, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 7 Years to 12 Years |
Eligibility |
Inclusion Criteria: - Diagnosis of ARDS, aged 7 to 12 years; - Indication of treatment with alveolar recruitment maneuver. Exclusion Criteria: - Clinical condition that does not allow alveolar recruitment maneuvers - Severe hypotension - Cardiac arrhythmia - Pneumothorax - Pneumatocele untreated. |
Country | Name | City | State |
---|---|---|---|
Brazil | Fundação Santa Casa de Misericórdia do Pará | Belém | Pará |
Lead Sponsor | Collaborator |
---|---|
Universidade Metodista de Piracicaba | Universidade do Estado do Pará |
Brazil,
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Kheir JN, Walsh BK, Smallwood CD, Rettig JS, Thompson JE, Gómez-Laberge C, Wolf GK, Arnold JH. Comparison of 2 lung recruitment strategies in children with acute lung injury. Respir Care. 2013 Aug;58(8):1280-90. doi: 10.4187/respcare.01808. Epub 2012 Dec — View Citation
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Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Driving pressure | The driving pressure, which indicates alveolar pressure variation and alveolar distension capacity, will be evaluated. | evaluation during two days | |
Primary | Alveolar collapse | the percentage of alveolar collapse, which indicates how much the pulmonary alveolus is without air. | evaluation during two days | |
Primary | Alveolar hiperdistension | the percentage of hyperdistended alveoli, which indicates that the alveoli are with excess air in their interior. | Evaluation during two days | |
Primary | Regional air ventilation | Regional air ventilation, which indicates how air is distributed in the lung, demonstrating the most ventilated and least ventilated areas in the lung. | Evaluation during two days |
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