Renal Artery Stenosis Clinical Trial
Official title:
Comparison of Stenting Versus Best Medical Therapy for Treatment of Ostial Renal Artery Stenosis: a Randomized Controlled Trial in Patients With Advanced Atherosclerosis.
Renal artery stenosis (RAS) usually refers to a disease of the large extra-renal arterial
vessels and most frequently is caused by atherosclerotic obstructions. The prevalence of
atherosclerotic RAS increases with age, male gender, traditional cardiovascular risk factors
(hypertension, diabetes, smoking, hyperlipidemia) and atherosclerotic comorbidities like
coronary artery or peripheral artery disease (PAD). A prevalence up to 40% has been reported
in patients with PAD. Undoubtedly, atherosclerotic RAS is a progressive disease, as more
than half of the patients exhibit an increasing degree of stenosis within five years after
diagnosis, and one out of five patients with a critical stenosis (>60%) suffers renal
atrophy and renal failure during this period. RAS may be treated conservatively by so called
best medical treatment, surgically, or by endovascular interventions using balloon
angioplasty and stenting.
The purpose of the investigators study is to determine the incidence and the predictors of
RAS in patients with PAD, and to compare the effect of renal artery stenting versus best
medical treatment in patients with hypertension and ostial renal artery stenosis in a
randomized controlled trial.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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