Clinical Trials Logo

Clinical Trial Summary

This study will use PBV technique to quantitatively assess the improvement of renal perfusion before and after endovascular treatment (EVT) of renal artery stenosis.


Clinical Trial Description

BACKGROUND: Renal artery stenosis (RAS) is one of the main reasons for secondary hypertension and renal failure, which etiologies include atherosclerosis, fibromuscular dysplasia and takayasu arteritis. Endovascular treatment under digital subtraction angiography (DSA) is an option to treat this disease. However, the technical success of this procedure is mainly based on morphology of its targeting renal artery without any quantified data towards renal blood perfusion. Thus, this study will try to solve how renal blood perfusion changes before and after endovascular treatment of renal artery stenosis.

DESIGN NARRATIVE:

This prospective cohort study will recruit patients with renal artery stenosis. PBV data will be obtained before and after their endovascular treatments. The volume of target kidney and its mean density of contrast from PBV data will be calculated as indicators for renal perfusion. And the relation between the percentage of stenosis and renal perfusion will be analyzed. The follow-up will last for one year. At 6-month and 12-month follow-up, DSA and PBV acquisition protocol will be undertaken again to evaluate renal blood perfusion in the long term. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03252639
Study type Observational
Source Peking Union Medical College Hospital
Contact Bao Liu, MD
Phone +86-10-69152502
Email liubao72@aliyun.com
Status Recruiting
Phase N/A
Start date November 2016
Completion date July 2018

See also
  Status Clinical Trial Phase
Completed NCT02528149 - Renal Arteries Dysplastic Aneurysms: Anatomopathological and Genetic Study N/A
Completed NCT02476526 - Safety of Low Dose IV Contrast CT Scanning in Chronic Kidney Disease Phase 4
Completed NCT00209391 - A Safety & Efficacy Clinical Study to Evaluate the Narrowing of the Renal Arteries While Using Gadodiamide Phase 3
Completed NCT01673373 - Renal Stent Placement for the Treatment of Renal Artery Stenosis in Patients With Resistant Hypertension N/A
Completed NCT02266394 - Hypoxia and Inflammatory Injury in Human Renovascular Hypertension Phase 1
Recruiting NCT02388139 - Cardiovascular, Renal and Metabolic Profile in Patients With Acute Myocardial Infarction (REN-ACS) N/A
Active, not recruiting NCT01023373 - Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy Phase 4
Recruiting NCT05603221 - Renal Perfusion Assessment in the Endovascular Treatment of Renal Artery Stenosis
Completed NCT00235157 - A Comparison of Coated and Uncoated Stents in Renal Artery Treatment. Phase 2
Completed NCT00001313 - Evaluation of Patients With Known or Suspected Heart Disease N/A
Not yet recruiting NCT05612438 - RADIX 2 RENAL STENT Post-Market Retrospective Study
Withdrawn NCT03914157 - Ultrasound Wave Therapy for Post-stenotic Microvascular Remodeling N/A
Completed NCT01128933 - Renal Fractional Flow Reserve in Renal Artery Stenting N/A
Recruiting NCT03594786 - Impact of Supra-renal Fixation of EVAR on Hemodynamics of Renal Arteries N/A
Completed NCT00885768 - Prevalence of Renal Artery Stenosis in Patients Referred for Cardiac Catheterization Phase 3
Completed NCT04423458 - Evaluation of Advanced US Tools in Assessing Allograft Complications
Recruiting NCT02655341 - Hydration Status Assessment Through Body Composition Monitoring in Patients With Acute Myocardial Infarction N/A
Completed NCT01576835 - Renal Artery Contrast-Free Trial Phase 4
Completed NCT01057316 - Formula PTX Renal Stent Clinical Study N/A
Completed NCT00631540 - REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent N/A