The Role of Uterine NK Cells and T Cell Cytokines in Recurrent Miscarriage

Recurrent Pregnancy Losses Clinical Trial

Official title: The Role of Uterine NK Cells and T Cell Cytokines in Recurrent Miscarriage.

Status Terminated

Clinical Trial Summary

The aim of the study is to evaluate the role of uterine natural killer cell(uNK)in recurrent pregnancy losses and the correlation between the numbers of it and embryo toxicity by measuring the level of the Th2 cytokines in normal reproductive profile and in patients with Recurrent Pregnancy Losses (RPL).

Clinical Trial Description

Office hysteroscopy examination of the patients at the luteal phase of the natural cycle (day17 to day 20),with endometrial biopsy using pipple curette from the region of the fundus, the biopsy sent to flow cytometry laboratory in South Egypt Cancer Institute to be examined for:

1.1. Phenotypic analysis of uterine natural killer cells:

1.2. Induction and detection of intracellular cytokines by flow Cytometry:

;

Related Conditions & MeSH terms

• Abortion, Habitual
• Abortion, Spontaneous
• Recurrent Pregnancy Losses

• NCT number: NCT01688284
• Study type: Interventional
• Source: Woman's Health University Hospital, Egypt
• Status: Terminated
• Phase: N/A
• Start date: March 2010
• Completion date: August 2012