| Eligibility |
Inclusion Criteria:
- Any histologically confirmed locally advanced recurrent endometrial adenocarcinoma
(except for carcinosarcoma), recurrent high-grade serous ovarian/primary
peritoneal/fallopian tube carcinoma, or deleterious BRCA mutant recurrent
ovarian/primary peritoneal/fallopian tube cancer for whom no curative option is
available will be eligible; any patient proven to have metastatic triple negative
breast cancer, defined from standard pathologic assays as negative for estrogen
receptor (ER) and progesterone receptor (PR) (< 10% tumor staining) will be eligible
- Patients may have unlimited prior chemotherapeutic regimens for management of
recurrent locally advanced endometrial carcinoma, recurrent ovarian carcinoma, or
metastatic triple negative breast cancer; treatment as frontline therapy for
metastatic disease is acceptable; patients who have received prior PARP inhibitors,
MTOR inhibitors, and/or AKT inhibitors are allowed to participate; patients may have
progressed on prior PARP inhibitor, MTOR inhibitor, or AKT inhibitor but they may not
have discontinued drug for toxicity
- With the exception of alopecia, any unresolved toxicities from prior chemotherapy
should be no greater than Common Terminology Criteria for Adverse Events (CTCAE)
(version 4.0) grade 1 at the time of starting study treatment
- Patients should have measurable disease as defined by Response Evaluation Criteria in
Solid Tumors (RECIST) 1.1; if no measurable disease is present, patients should have
assessable disease such as pleural effusion, ascites, with cancer antigen 125 (CA125)
Gynecological Cancer Intergroup (GCIG) criteria
- Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of
0 or 1
- Women of child-bearing potential and their partners must agree to use contraception
(hormonal or barrier method of birth control; abstinence) from study entry until 30
days after last dose of study drug; male partners should be instructed to use
contraception during the study period; women of child-bearing potential (intact
uterus) should have a negative serum pregnancy test; if a woman becomes pregnant or
suspects she is pregnant while on study, she should tell her treating physician
immediately; female patients must have evidence of non-child-bearing potential by
fulfilling 1 of the following at screening: a) post-menopausal defined as > 50 years
old and amenorrheic for >= 12 consecutive months following cessation of all exogenous
hormonal treatments; b) documentation of irreversible surgical sterilization by
hysterectomy, bilateral oophorectomy or bilateral salpingectomy, but not tubal
ligation
- Women must not breast-feed while taking the study medications
- Absolute neutrophil count >= 1,500/mcL (measured within 28 days prior to
entry/randomization)
- Hemoglobin >= 10 gm/dL (measured within 28 days prior to entry/randomization)
- Platelets >= 100,000/mcL (measured within 28 days prior to entry/randomization)
- Presence of < 4% blasts on hematologic studies (measured within 28 days prior to
entry/randomization)
- Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (measured within 28
days prior to entry/randomization)
- Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit
of normal unless the liver is involved with tumor, in that case, ALT/AST must be =< 5
x ULN (measured within 28 days prior to entry/randomization)
- Creatinine clearance > 50 mL/min (assessed by Cockcroft Gault estimation) (measured
within 28 days prior to entry/randomization)
- Patients with type II diabetes mellitus that is well controlled by dietary measures
alone and have a hemoglobin A1c (HgA1c) < 8% are eligible to participate; patients
found to have a fasting glucose >= 7 mmol/L (>= 126 mg/dL) or glycosylated hemoglobin
> 8% (64 mmol/mol) at screening should be assessed for appropriate management
according to local policy; those in whom dietary measures alone provide good diabetic
control will be eligible for inclusion; type I or II diabetes mellitus requiring
either insulin or oral hypoglycemics for routine management will be excluded
- Patients must be able to swallow and tolerate oral medications and not have
gastrointestinal illnesses that would preclude absorption of AZD2014, AZD5363, or
olaparib (e.g. uncontrolled nausea, vomiting, or diarrhea; malabsorption syndrome;
ulcerative disease)
- Participants' life expectancy must be > 4 months
- Patients must be able to understand and willing to sign an informed consent
- FOR EXPANSION PHASE ONLY: For the expansion phase, patients must have measurable
disease accessible for biopsy
- FOR EXPANSION PHASE ONLY: For the expansion phase, patients must have archival
specimens from the time of primary or recurrence diagnosis
Exclusion Criteria:
- Patients receiving any other investigational agents or any additional anti-cancer
agents
- Patients who have endometrial carcinosarcoma; patients with ovarian cancer who have
histology other than high-grade serous in the absence of a deleterious BRCA mutation;
if the patient has a deleterious BRCA mutation, any histology will be accepted
- Patients who have recurrences that are amenable to potentially curative treatment with
radiation therapy or surgery
- Patients who have a history of other malignancies except for basal cell or squamous
cell skin cancer, in situ cervical cancer, unless they have been disease-free for at
least five years; patients may have dual primaries of endometrial, ovarian or breast
cancer
- Patients who have a history of myelodysplastic syndrome
- Patients who have symptomatic, uncontrolled spinal cord compression and/or brain
metastases; a scan to confirm absence of brain metastasis is not required; patients
can receive a stable dose of corticosteroids (except those prohibited per protocol)
before/during study if these were started at least 28 days prior to entry
- Patients who have had prior chemotherapy, biological therapy, radiation therapy,
androgens, thalidomide, immunotherapy, other anticancer agents, and any
investigational agents within 28 days of starting study treatment (not including
palliative radiotherapy at focal sites), or corticosteroids that are prohibited per
protocol within 14 days of starting study treatment
- Patients who have had major surgery within 28 days prior to entry into the study or be
recovering from any effects of surgery; patients who have had minor surgery within 2
weeks prior to entry into the study
- Patients who have a resting electrocardiogram (ECG) with a Fridericia corrected QT
(QTcF) interval of >= 470 msec at 2 or more time points within a 24 hour period or a
family history of long QT syndrome
- Patients who have required a blood transfusion within 28 days prior to study start
- Patients who have received any hemopoietic growth factors (e.g., filgrastim [G-CSF],
sargramostim [GM-CSF]) within 2 weeks prior to study start
- Patients receiving certain medications and/or substances that are prohibited within
stated wash-out periods
- Patients with known hypersensitivity to olaparib, AZD5363, AZD2014 or any of their
excipients; patients with a history of hypersensitivity to drugs with a similar
chemical structure or class to olaparib, AZD5363, or AZD2014
- Patients who have experienced intolerable adverse events per treating investigator due
to other PARP inhibitors, mTOR inhibitors, PI3 kinase inhibitors, or AKT inhibitors
- Patients who have experienced any of the following procedures or conditions currently
or in the preceding 12 months: a) coronary artery bypass graft; b) angioplasty; c)
vascular stent; d) myocardial infarction; e) angina pectoris; f) congestive heart
failure New York Heart Association grade >= 2; g) ventricular arrhythmias requiring
continuous therapy; h) supraventricular arrhythmias including atrial fibrillation,
which are uncontrolled; i) hemorrhagic or thrombotic stroke, including transient
ischemic attacks or any other central nervous system bleeding
- Patients who have abnormal echocardiogram (ECHO) or multi-gated acquisition scan
(MUGA) at baseline (left ventricular ejection fraction [LVEF] < 50%); appropriate
correction to be used if a MUGA is performed
- Patients with torsades de pointes within 12 months of study entry
- Patients with uncontrolled hypotension (systolic blood pressure < 90 mmHg and/or
diastolic blood pressure < 50 mmHg)
- Patients with proteinuria (3+ on dipstick or 300 mg/dL on urine analysis or > 500
mg/dL/24 hours)
- Patients with diabetes type I or uncontrolled type II (HbA1c > 8 % assessed locally)
as judged by the investigator
- As judged by the investigator, any evidence of severe or uncontrolled systemic
diseases (e.g., severe hepatic impairment, interstitial lung disease [bilateral,
diffuse, parenchymal lung disease], uncontrolled chronic renal diseases
[glomerulonephritis, nephritic syndrome, Fanconi syndrome or renal tubular acidosis]),
or current unstable or uncompensated respiratory or cardiac conditions, or
uncontrolled hypertension (blood pressure >= 140/90), active bleeding diatheses or
active infection including hepatitis B, hepatitis C, and human immunodeficiency virus;
screening for chronic conditions is not required
- As judged by the investigator, the patient is unsuitable to participate in the study
and the patient is unlikely to comply with study procedures, restrictions, and
requirements
- FOR EXPANSION PHASE ONLY: Lack of accessible tumor for biopsy
- Lack of archival specimens from the time of primary or recurrence diagnosis
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