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Molecular Study and Precision Medicine for Colorectal Cancer — MSPM  

Advanced Colorectal Carcinoma Clinical Trial

Official title:
Precision Medicine for Advanced or Recurrent Colorectal Cancer Directed by High-throughput Sequencing and Tumor Organoids Model

Clinical Trial Summary

Researchers collect specimens from advanced or recurrent colorectal cancer (CRC) patients to conduct molecular profiling and establish tumor organoids (PDOs)/ patient-derived xenografts (PDXs). The aim of this study is to identify clinical actionable targets and predict in vivo response of the tumor to targeted drugs by using PDOs/ PDXs. And the above-mentioned studies will provide the patients with potential personalized cancer treatment options.

Clinical Trial Description

Patient-derived organoid is a model that can recapitulate the histology and behavior of the cancer from which it is derived, and is increasingly used as a tool for drug development in pre-clinical settings. Clinical treatment option of colorectal cancer now is quite limited. By molecular profiling, clinical actionable alterations may be identified. And according to the genomic investigation results, we can find the matched targeted drugs, following further testing in the organoids and PDXs. This will provide an opportunity to guide the precision medicine. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05883683
Study type Observational
Source Wuhan Union Hospital, China
Contact Zheng Wang, MD/PhD
Phone +86 2785726612
Email zhengwang@hust.edu.cn
Status Not yet recruiting
Phase
Start date July 1, 2023
Completion date July 1, 2026
View Details
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