Recurrent Abortion Clinical Trial
Official title:
Histopathological Evaluation of Product of Conception in Sporadic and Recurrent Abortions
1. To evaluate histopathological findings of products of conception in both sporadic and
recurrent miscarriage.
2. To determine the prevalence of chronic histiocytic intervillositis in both sporadic and
recurrent miscarriage.
Early miscarriage is a term used to describe the loss of pregnancy within the first 12 weeks
of gestation .This diagnosis concerns 10-15% of all pregnancies and is made based on
additional tests such as serial determinations of chorionic gonadotropin concentration and
imaging examinations ultrasonography. Depending on the clinical presentation and results of
ultrasonography, miscarriages can be divided into complete spontaneous miscarriage, and
incomplete miscarriage, when the width of the echo of residual tissues in the uterine cavity
exceeds 10 mm on ultrasonography and is accompanied by the presence of clinical symptoms such
as vaginal bleeding and abdominal pain .The other type of miscarriage is defined as retained
products of conception (RPOC) and refers to the state when the gestational sac contains the
embryo with crown-rump length (CRL) of > 7 mm but embryonic cardiac activity is invisible.
Empty gestational sac is diagnosed when the gestational sac with a diameter of > 25 mm and
without an embryo is visible in the uterine cavity on ultrasonography .
Histopathological examination of products of conception is an integral and a routine
component of the management of patients with early pregnancy failure . Two important primary
reasons for such an examination are to confirm the presence of an intrauterine gestation and
to exclude gestational trophoblastic disease in the form of partial or complete hydatidiform
mole .
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