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Recurrence clinical trials

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NCT ID: NCT06311227 Not yet recruiting - Clinical trials for Recurrent Hairy Cell Leukemia

Venetoclax for the Treatment of Patients With Relapsed Hairy Cell Leukemia

Start date: May 20, 2024
Phase: Phase 2
Study type: Interventional

This phase II trial tests how well venetoclax works in treating patients with hairy cell leukemia that has come back after a period of improvement (relapsed). Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival.

NCT ID: NCT06308575 Not yet recruiting - Clinical trials for Metastatic Olfactory Neuroblastoma

A Phase II Study of Rivoceranib for Patients With Recurrent or Metastatic Olfactory Neuroblastoma

Start date: September 30, 2024
Phase: Phase 2
Study type: Interventional

To learn if rivoceranib can help to control olfactory neuroblastoma. The safety of this drug in participants with olfactory neuroblastoma will also be studied.

NCT ID: NCT06300528 Not yet recruiting - Clinical trials for Recurrent Mantle Cell Lymphoma

Pemigatinib for the Treatment of Patients With Relapsed or Refractory Mantle Cell Lymphoma or Marginal Zone Lymphoma

Start date: April 30, 2024
Phase: Phase 2
Study type: Interventional

This phase II trial tests how well pemigatinib works in treating patients with mantle cell lymphoma (MCL) or marginal zone lymphoma (MZL) that has come back after a period of improvement (relapsed) or that does not respond to treatment (refractory). Pemigatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

NCT ID: NCT06258564 Not yet recruiting - Recurrence Clinical Trials

The Adjuvant Effect of HPV Vaccination on Recurrence of Cervical Precancer or Carcinoma in Women Undergoing Conization

Start date: May 1, 2024
Phase:
Study type: Observational

Assessment of the association between human papillomavirus vaccination (HPV) and recurrences of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) in women undergoing conization.

NCT ID: NCT06254326 Not yet recruiting - Clinical trials for Recurrent Oligodendroglioma

ADAGiO: Adoptive Cellular Therapy for the TreAtment of Recurrent OliGodendrogliOma (OG) Adult Patients

ADAGiO
Start date: June 2024
Phase: Phase 1
Study type: Interventional

This study will enroll 6 DLT evaluable subjects (up to 12 patients total) where we will evaluate feasibility and safety of adoptive cellular therapy in patients with recurrent or progressive oligodendroglioma WHO grade 2 and WHO grade 3.

NCT ID: NCT06253117 Not yet recruiting - Clinical trials for Recurrent Acute Pancreatitis

Evaluation of Pirfenidone as a Novel Therapeutic Strategy Against Recurrent Acute Pancreatitis.

PirfenidoneRAP
Start date: June 1, 2024
Phase: Phase 2
Study type: Interventional

This clinical will evaluate the safety, tolerability and early efficacy of pirenidone in patients with recurrent acute pancreatitis.

NCT ID: NCT06252792 Not yet recruiting - Multiple Myeloma Clinical Trials

Dara-PD in the Treatment of Patients With First Relapse of Multiple Myeloma

Start date: May 10, 2024
Phase:
Study type: Observational

The investigators designed the present study with the aim of observing the efficacy and survival of D-Pd regimen compared with other regimens (including D-KPD,VPd, KPd, IPd, Pd) in the same period for the first relapse of MM patients receiving RVD regimen, so as to provide a safe and effective treatment strategy for the first relapse of MM patients.

NCT ID: NCT06250140 Not yet recruiting - Internal Hemorrhoid Clinical Trials

Recurrence Rate of Minimally Invasive Endoscopic Treatment of Internal Hemorrhoids

Start date: February 1, 2024
Phase:
Study type: Observational

2.1 Main objective: To observe the short-term and long-term recurrence rates of various endoscopic minimally invasive treatment methods for internal hemorrhoids and different time points of endoscopic minimally invasive treatment for internal hemorrhoids in patients with grade I-III internal hemorrhoids 2.2 Secondary objective: To observe the safety and efficacy of endoscopic minimally invasive treatment of internal hemorrhoids

NCT ID: NCT06249230 Not yet recruiting - Clinical trials for Recurrent Miscarriage

The Analysis of Risk Factors for Recurrent Pregnancy Loss and Prediction of Pregnancy Loss Risk

Start date: January 31, 2024
Phase:
Study type: Observational

Based on the comprehensive etiological screening results of patients with recurrent pregnancy loss, including basic characteristics, coagulation function indicators, autoimmune indicators, endocrine indicators, and gynecological ultrasound examination results, as well as the outcome of subsequent pregnancy after the patient's visit, analyze the independent risk factors affecting recurrent pregnancy loss, construct and validate an abortion risk prediction model to predict the risk of subsequent pregnancy loss in patients with recurrent pregnancy loss, and classify the patient's risk, Screening high-risk populations and guiding clinical early intervention and active treatment to improve pregnancy success rates.

NCT ID: NCT06247787 Not yet recruiting - Clinical trials for Refractory Acute Myeloid Leukemia

A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy

Start date: July 12, 2024
Phase: Phase 1
Study type: Interventional

This phase I trial tests the safety, side effects, and best dose of imetelstat in combination with fludarabine and cytarabine in treating patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) or juvenile myelomonocytic leukemia (JMML) that has not responded to previous treatment (refractory) or that has come back after a period of improvement (recurrent). Imetelstat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as fludarabine and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving imetelstat in combination with fludarabine and cytarabine may work better in treating patients with refractory or recurrent AML, MDS, and JMML.