Radiotherapy Clinical Trial
Official title:
A Pilot Study to Evaluate the Role of Cyclooxygenase Pathway in Radiation Therapy and Chemoradiation Therapy Induced Mucositis in Head and Neck Cancer Patients
This study will evaluate the role of cyclooxygenase pathways in radiation-induced and chemoradiation-induced mucositis.
Oral mucositis is a significant toxicity of radiation therapy and chemoradiation therapy in
head and neck cancer patients. However the mechanisms that induce such mucositis are not
completely understood. Previous work evaluating mucositis in bone marrow transplant patients
has suggested that prostaglandin levels may be associated with the appearance of mucositis.
The present study will measure the levels in saliva of the prostaglandins PGE2 and PGI2
before, during, immediately after, and several weeks after radiotherapy for head and neck
cancer. These salivary levels will be correlated with clinical observation of mucositis and
patient reporting of pain levels.
Improved understanding of the mechanism of mucositis may lead to the development of more
effective targeted agents to prevent this problem.
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Observational Model: Case-Only, Time Perspective: Prospective
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