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NCT05458635 Clinical Trial

Predictors of Pulmonary Hypertension in Patients With Hypersensitivity Pneumonitis

Pulmonary Hypertension Clinical Trial

Official title:
Predictors of Pulmonary Hypertension in Patients With Hypersensitivity Pneumonitis

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05458635
Other study ID # MS-131-2019
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date August 1, 2019
Est. completion date March 15, 2021

Study information
Verified date July 2022
Source Cairo University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Hypersensitivity pneumonitis (HP) is a complex immune mediated disorders caused by repeated inhalation of and sensitization to wide range of antigens including organic particles and chemical compounds, leading to exaggerated immuneresponse. Hypersenstivity pneumonitis is a common form of diffuse parenchymal lung diseases in Egypt .Pulmonary hypertension has been found as a complication of a number of diseases affecting the lung interstitium, including hypersensitivity pneumonitis, with subsequent affection of the life expectancy Rationale of the study: to find predictors for the development of pulmonary hypertension in patients with hypersensitivity pneumonitis

Description:

Cross sectional study included 60 patients with established diagnosis of HP , work up includes history of exposure, clinical examination, HRCT chest, ABGs,6MWD, desaturation degree , spirometry, echocardiography and right heart catheter in patients with high echo probability of PH.

Recruitment information / eligibility
Status Completed
Enrollment 60
Est. completion date March 15, 2021
Est. primary completion date October 31, 2020
Accepts healthy volunteers No
Gender All
Age group 29 Years to 55 Years
Eligibility Inclusion Criteria: - All patients with confirmed diagnosis of Hypersensitivity pneumonitis Exclusion Criteria: - Other interstitial lung diseases

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Right heart catheter
Right heart catheterization was performed for 4 cases with high probability of pulmonary hypertension using multi-lumen swan ganz catheter.

Locations
Country Name City State
Egypt Kasr alainy school of medicine Cairo

Sponsors (1)
Lead Sponsor Collaborator
Cairo University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Percentage of pulmonary hypertension in patients with HP primary oucome 6 months
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