Pulmonary Hypertension Clinical Trial
Official title:
Pulmonary Arterial Denervation in Patients With Pulmonary Hypertension Associated With the Left Heart Failure: a Randomised Controlled Trial
A number of 100 patients with pulmonary hypertension associated with the left Heart failure scheduled for elective pulmonary arterial denervation (PADN) are randomized 1:1 to either PADN or control group.
Heart failure patients must have completed the right heart catheterization. All the patients
accepted the optimal medical therapies,including diuretics, Nitrate esters, β-blockers, ACE
inhibitors or receptor blocker aldosterone antagonists and/or digoxin).The patients of
pulmonary hypertension are defined into two groups: "passive" pulmonary hypertension(mPAP≥25
mmHg, PCWP>15 mmHg and pulmonary vascular resistance<3 woods unit) increase due to backward
transmission of increased left ventricular filling pressure, "reactive" pulmonary
hypertension (mPAP≥25 mmHg, PCWP>15 mmHg and pulmonary vascular resistance >3 woods unit)
increase in resistance due to either pulmonary vasoconstriction or structural changes in the
pulmonary vasculature.
All the "reactive" pulmonary hypertension patients are eligible for the randomized study in
PADN group or control group according to the computer generated random table.
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