Pulmonary Hypertension Clinical Trial
Official title:
Real-Time MRI Right Heart Catheterization Using Passive Catheters
Background:
- Currently, heart catheterization procedures are guided by X-rays. Researchers are
developing new techniques to perform heart catheterization without the use of X-rays by
investigating possible uses of magnetic resonance imaging (MRI) scans. To study these uses,
researchers are interested in performing a part of the standard X-ray catheterization
procedure using MRI on individuals who are scheduled to have heart catheterization.
Objectives:
- To examine the safety and feasibility of right-heart catheterization using MRI-guided
catheters.
Eligibility:
- Individuals at least 21 years of age who are undergoing a medically necessary heart
catheterization procedure.
Design:
- The research MRI procedure will be performed either before or after standard X-ray
guided heart catheterization.
- Participants will be transferred from an X-ray table onto an MRI table and advanced into
the scanner. Under MRI guidance, a MRI-compatible catheter will be used to measure blood
pressure and blood oxygen levels in the heart, and MRI scanning will be performed for
approximately 30 minutes.
Heart catheterization is a minimally invasive procedure to measure pressure and inject dye
into specific heart cavities. Heart catheterization usually uses X-ray guidance, which
involves radiation exposure and which fails to visualize soft tissue.
We have developed real-time magnetic resonance imaging (MRI) to guide heart catheterization
with tissue visualization but without X-ray radiation. In the first phase of this protocol we
showed that comprehensive right-sided heart catheterization is feasible in adult patients,
using commercially available MRI-compatible ( passive ) catheters.
In the second phase of the protocol, we began performing systematic right-sided heart
catheterization without X-ray whenever possible. We will assess the hearts response to
hemodynamic provocation during MRI catheterization tailored to the patient s problem. We will
use this protocol to further refine the technique
If successful, this will enable future testing of devices for adult and pediatric MRI-guided
catheterization, such as special active wire guides, which may lead to new non-surgical
treatments of cardiovascular disease.
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