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MK-5475 in Participants With Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease (PH-COPD) (MK-5475-006)

Pulmonary Hypertension Clinical Trial

Official title:
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Dose MK-5475 in Participants With Pulmonary Hypertension Associated With COPD

Clinical Trial Summary

The primary objectives of this study are to assess the safety/tolerability and efficacy (by evaluating changes in pulmonary vascular resistance [PVR] and pulmonary blood volume [PBV]) of MK-5475 in participants with pulmonary hypotension associated with chronic obstructive pulmonary disease (PH-COPD). The primary hypothesis is that 28 days of MK-5475 treatment is superior to placebo treatment in reduction of PVR.

Clinical Trial Description

Part 1 of this study will assess safety, tolerability, and PK of MK-5475 compared to placebo. Part 2 will assess safety, tolerability, PK, and changes in PVR and PBV of MK-5475 compared to placebo. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04370873
Study type Interventional
Source Merck Sharp & Dohme LLC
Contact
Status Completed
Phase Phase 1
Start date June 5, 2020
Completion date January 12, 2022
View Details
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